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Fig. 5. Antitumor efficacy of ERY974 in immunocompetent human CD3 transgenic mice. Antitumor efficacy of ERY974 in immunocompetent human CD3 transgenic.

Published byEustace Gregory Tyler Modified over 5 years ago

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Presentation on theme: "Fig. 5. Antitumor efficacy of ERY974 in immunocompetent human CD3 transgenic mice. Antitumor efficacy of ERY974 in immunocompetent human CD3 transgenic."— Presentation transcript:

1 Fig. 5. Antitumor efficacy of ERY974 in immunocompetent human CD3 transgenic mice.
Antitumor efficacy of ERY974 in immunocompetent human CD3 transgenic mice. (A) Histopathological analysis of Hepa1-6/hGPC3 and LLC1/hGPC3 tumors. Tumor tissue samples taken 3 days after administering vehicle or ERY974 (5 mg/kg) were stained as indicated. H&E, hematoxylin and eosin. (B) Gene expression analysis in Hepa1-6/hGPC3 and LLC1/hGPC3 tumors. RNA from tumors treated with vehicle or ERY974 was used for RNA-seq. Each group was tested in triplicate (n = 3). Z scores were calculated using log2-transformed fragments per kilobase of exon per million mapped fragments values for all target genes. (C) Antitumor efficacy of ERY974 and immune checkpoint inhibitors. Values represent means + SD (n = 5). *P < 0.05 between vehicle group and the antibody treatment group at day 25 determined by Dunn’s multiple comparisons test. Arrows indicate the timing of antibody administration. Takahiro Ishiguro et al., Sci Transl Med 2017;9:eaal4291 Published by AAAS

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