Long-term treatment with nipradilol, a nitric oxide–releasing β-adrenergic blocker, enhances postischemic recovery and limits infarct size Yoshihiro.

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Presentation transcript:

Long-term treatment with nipradilol, a nitric oxide–releasing β-adrenergic blocker, enhances postischemic recovery and limits infarct size Yoshihiro Suematsu, MD, Toshiya Ohtsuka, MD, Hitoshi Horimoto, MD, Katsuhide Maeda, MD, Yasunari Nakai, MD, Shigetoshi Mieno, MD, Shinichi Takamoto, MD The Annals of Thoracic Surgery Volume 73, Issue 1, Pages 173-179 (January 2002) DOI: 10.1016/S0003-4975(01)03234-9

Fig 1 Experimental protocol showing the treatment groups. (GI = global ischemia group; IP = ischemic preconditioning group; ARG = l-arginine group; NPL+IP = nipradilol plus ischemic preconditioning group; NPL = nipradilol group; NOx = nitrates and nitrites.) The Annals of Thoracic Surgery 2002 73, 173-179DOI: (10.1016/S0003-4975(01)03234-9)

Fig 2 The effects of global ischemia (GI), ischemic preconditioning (IP), l-arginine (ARG), nipradilol plus ischemic preconditioning (NPL+IP), and nipradilol (NPL) on left ventricular end-diastolic pressure. Significant differences during reperfusion at p < 0.05 versus NPL are designated by * and p < 0.05 versus GI by #. The Annals of Thoracic Surgery 2002 73, 173-179DOI: (10.1016/S0003-4975(01)03234-9)

Fig 3 The effects of global ischemia (GI), ischemic preconditioning (IP), l-arginine (ARG), nipradilol plus ischemic preconditioning (NPL+IP), and nipradilol (NPL) on left ventricular peak developed pressure. Significant differences during reperfusion at p < 0.05 versus NPL are designated by *. The Annals of Thoracic Surgery 2002 73, 173-179DOI: (10.1016/S0003-4975(01)03234-9)

Fig 4 The effects of global ischemia (GI), ischemic preconditioning (IP), l-arginine (ARG), nipradilol plus ischemic preconditioning (NPL+IP), and nipradilol (NPL) on coronary flow. Significant differences during reperfusion at p < 0.05 versus NPL are designated by *. The Annals of Thoracic Surgery 2002 73, 173-179DOI: (10.1016/S0003-4975(01)03234-9)

Fig 5 The effects of global ischemia (GI), ischemic preconditioning (IP), l-arginine (ARG), nipradilol plus ischemic preconditioning (NPL+IP), and nipradilol (NPL) on infarct size (percent of left ventricular volume). Significant differences in infarct size at p < 0.05 versus NPL are designated by * and p < 0.05 versus GI by #. The Annals of Thoracic Surgery 2002 73, 173-179DOI: (10.1016/S0003-4975(01)03234-9)

Fig 6 The effects of global ischemia (GI), ischemic preconditioning (IP), l-arginine (ARG), nipradilol plus ischemic preconditioning (NPL+IP), and nipradilol (NPL) on nitrates and nitrites 60 minutes after reperfusion. Each value is presented as a percentage of the preischemic value. Significant differences during reperfusion at p < 0.05 versus GI are designated by * and p < 0.05 versus IP by #. The Annals of Thoracic Surgery 2002 73, 173-179DOI: (10.1016/S0003-4975(01)03234-9)

Fig 7 Lipid peroxidation in the global ischemia (GI) and nipradilol (NPL) groups. (a) Baseline level of thiobarbituric acid reactive substances before ischemia–reperfusion. (b) Thiobarbituric acid reactive substances, after 20 minutes’ ischemia and 60 minutes’ reperfusion. Significant differences at p < 0.05 versus hearts in (a) are designated by # and p < 0.05 versus the GI group by *. The Annals of Thoracic Surgery 2002 73, 173-179DOI: (10.1016/S0003-4975(01)03234-9)