Presentation is loading. Please wait.

Presentation is loading. Please wait.

Gefeng Li, John A. Sullivan, John M. You, Richard I. Hall 

Similar presentations


Presentation on theme: "Gefeng Li, John A. Sullivan, John M. You, Richard I. Hall "— Presentation transcript:

1 Effect of Pressure on Myocardial Function After 6-Hour Preservation With Blood Cardioplegia 
Gefeng Li, John A. Sullivan, John M. You, Richard I. Hall  The Annals of Thoracic Surgery  Volume 65, Issue 1, Pages (January 1998) DOI: /S (97)01014-X

2 Fig. 1 Preservation model for donor heart with continuous blood cardioplegia. (P = pressure transducer; T = thermometer.) The Annals of Thoracic Surgery  , DOI: ( /S (97)01014-X)

3 Fig. 2 Pig cross-circulation support model for donor heart reperfusion. (HE = heat exchanger; P = pressure transducer; T = thermometer.) The Annals of Thoracic Surgery  , DOI: ( /S (97)01014-X)

4 Fig. 3 Left ventricular (LV) work for experimental groups during reperfusion after 6 hours’ preservation. Group 1 = controls; group 2 = hearts arrested with cold Queen’s cocktail; group 3 = hearts arrested with cold University of Wisconsin solution; and groups 4 and 5 = hearts arrested with cold blood cardioplegia and then continuously perfused at a pressure of 80 cm H2O or 40 cm H2O, respectively, for 6 hours. ∗ = p < versus groups 1 and 5; ∗∗ = p < versus all other groups.) The Annals of Thoracic Surgery  , DOI: ( /S (97)01014-X)

5 Fig. 4 Left ventricular end-diastolic pressure–left ventricular end-diastolic volume relationship at varying intervals of reperfusion. Symbols represent the means at each end-diastolic volume level for every individual treatment group. The solid line demonstrates linear regression, and the dotted line shows 95% confidence interval. (A) Thirty minutes of reperfusion. The slope of the BC80 group differed from slopes of all other groups (p < 0.001). The BC40 slope was higher than slopes of control (p < 0.023) and UW groups (p < 0.001), significantly lower than that of BC80 group (p < 0.001), and not different from that of QS group. (B) Sixty minutes of reperfusion. The slope of the BC80 group is significantly higher than slopes of the control and UW groups (p < and p < 0.011, respectively). The BC40 slope is significantly different from that of the UW group (p < 0.001). (C) Ninety minutes of reperfusion. The slope of the BC80 group is the highest (p < 0.001). (BC40 versus UW, p = ) (D) One hundred twenty minutes of reperfusion. The BC80 slope is higher than slopes of controls, QS group, UW group, or BC40 group (p = 0.001, p = 0.004, p = 0.001, and p = 0.02, respectively). The slope of the BC40 group differs from slopes of control (p = 0.033) and UW groups (p = 0.046). (BC80 and BC40 = hearts arrested with cold blood cardioplegia and then continuously perfused at pressures of 80 cm H2O and 40 cm H2O, respectively; QS = hearts arrested with cold Queen’s cocktail followed by 6 hours’ cold storage; UW = hearts arrested with cold University of Wisconsin solution followed by 6 hours’ cold storage; The Annals of Thoracic Surgery  , DOI: ( /S (97)01014-X)

6 Fig. 5 Coronary blood flow (COF) for all groups at 30, 60, 90, and 120 minutes of reperfusion. (∗, ∗∗ = p < versus other groups; see Fig. 4 legend for groups.) The Annals of Thoracic Surgery  , DOI: ( /S (97)01014-X)

7 Fig. 6 Coronary vascular resistance (CVR) for all groups at 30, 60, 90, and 120 minutes of reperfusion. (∗ = p < versus other groups; see Fig. 4 legend for groups.) The Annals of Thoracic Surgery  , DOI: ( /S (97)01014-X)


Download ppt "Gefeng Li, John A. Sullivan, John M. You, Richard I. Hall "

Similar presentations


Ads by Google