Hedi H Schreurs, Marianne J Wijers, Y

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Heparin-coated bypass circuits: effects on inflammatory response in pediatric cardiac operations Hedi H Schreurs, Marianne J Wijers, Y.John Gu, MD, PhD, Wim van Oeveren, PhD, Ron T van Domburg, MSc, Johan H de Boer, MD, Ad J.J.C Bogers, MD, PhD The Annals of Thoracic Surgery Volume 66, Issue 1, Pages 166-171 (July 1998) DOI: 10.1016/S0003-4975(98)00348-8

Fig 1 Postoperative central body temperature in pediatric patients perfused either with the extracorporeal circuit with Carmeda BioActive Surface (CBAS, n = 9) or without (Control, n = 10). (Point-by-point analysis, ∗p < 0.05, ∗∗p < 0.01; area under the curve analysis, not significant). The Annals of Thoracic Surgery 1998 66, 166-171DOI: (10.1016/S0003-4975(98)00348-8)

Fig 2 Central body temperature at 4 hours and 12 hours in intensive care unit (ICU). Significant difference in patients with temperature above 38°C (at 4 hours CBAS 2 versus Control 7, p < 0.05; at 12 hours CBAS 0 versus Control 5, p < 0.01). (CBAS = Carmeda BioActive Surface.) The Annals of Thoracic Surgery 1998 66, 166-171DOI: (10.1016/S0003-4975(98)00348-8)

Fig 3 Terminal complement complex (TCC) during and after cardiopulmonary bypass (CPB) in pediatric patients perfused either with the extracorporeal circuit with Carmeda BioActive Surface (CBAS, n = 9) or without (Control, n = 10). Samples taken as described in the text. (PreCPB = after induction of anesthesia; 20′CPB = 20 minutes after start of CPB; −5′X-off = 5 minutes before declamping; 5′X-off = 5 minutes after declamping; endCPB = at termination of CPB; 20′Prot = 20 minutes after starting the administration of protamine.) The Annals of Thoracic Surgery 1998 66, 166-171DOI: (10.1016/S0003-4975(98)00348-8)

Fig 4 Soluble form of E-selectin (sE-Selectin) during and after cardiopulmonary bypass (CPB) in pediatric patients perfused either with the extracorporeal circuit with the Carmeda Bioactive Surface (CBAS, n = 9) or without (Control, n = 10). Samples taken as described in the text. (PreCPB = after induction of anesthesia; 20′CPB = 20 minutes after start of CPB; −5′X-off = 5 minutes before declamping; 5′X-off = 5 minutes after declamping; endCPB = at termination of CPB; 20′Prot = 20 minutes after starting the administration of protamine.) (Point-by-point analysis, ∗p < 0.05; area under the curve analysis, not significant). The Annals of Thoracic Surgery 1998 66, 166-171DOI: (10.1016/S0003-4975(98)00348-8)

Fig 5 β-Thromboglobulin released from activated platelets during and after cardiopulmonary bypass (CPB) in pediatric patients perfused either with the extracorporeal circuit with the Carmeda Bioactive Surface (CBAS, n = 9) or without (Control, n = 10). Samples taken as described in the text. (PreCPB = after induction of anesthesia; 20′CPB = 20 minutes after start of CPB; −5′X-off = 5 minutes before declamping; 5′X-off = 5 minutes after declamping; endCPB = at termination of CPB; 20′Prot = 20 minutes after starting the administration of protamine.) (Point-by-point analysis, ∗p < 0.05; area under the curve analysis, not significant). The Annals of Thoracic Surgery 1998 66, 166-171DOI: (10.1016/S0003-4975(98)00348-8)