Skeletal muscle contraction

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Presentation transcript:

Skeletal muscle contraction Contraction, force and tension Sliding Filament Theory of Contraction Contraction cycle Regulation of the contraction cycle

Muscle contraction Movement or resist a load (force) Load is the weight or force that opposes the contraction of a muscle Tension is the force created by a muscle Need ATP to generate tension

Observations during muscle contraction Muscle shortens when it moves a load. (When muscle contracts, it does not always shorten)

Observations during muscle contraction: A band does not shorten during contraction.

How about force without movement? Sliding filament theory of contraction: movement and force Resting length How about force without movement?

During contraction Z discs move closer together Sarcomere shortens A band same length I band reduced H band reduced

What pushes the actin filaments into the myosin? Cross-bridges link myosin to actin Power stroke: myosin head binds to actin  myosin head release actin. Repeated many times. Myosin molecules are flexible ATP causes movement of myosin molecules

Myosin A motor protein Converts chemical bond energy of ATP to mechanical energy of motion Each myosin as ATPase Energy from ATP hydrolysis is stored as potential energy in the myosin molecule, and is used to create the power stroke.

Why don’t actin and myosin continuously bind together? ATP is usually available Actin’s binding site for myosin is revealed only during cross-bridge (binding). During relaxation, actin’s binding site for myosin is concealed