Redox Control of Mitochondrial Calcium Uptake

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Redox Control of Mitochondrial Calcium Uptake Nicolas Demaurex, Manon Rosselin Molecular Cell Volume 65, Issue 6, Pages 961-962 (March 2017) DOI: 10.1016/j.molcel.2017.02.029 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Oxidation of Cys97 Activates the Mitochondrial Ca2+ Uniporter Upon oxidative stress, mitochondrial Ca2+ uniporter (MCU) senses mitochondrial ROS production through the oxidation of a matrix-facing cysteine (Cys) residue at position 97. S-glutathionylation of Cys97 induces a conformational change that promotes the clustering of MCU channels and their persistent activation. Sustained mitochondrial Ca2+ uptake decreases respiratory functions and increases mitochondrial ROS levels, leading to mitochondrial [Ca2+] overload-induced cell death. Molecular Cell 2017 65, 961-962DOI: (10.1016/j.molcel.2017.02.029) Copyright © 2017 Elsevier Inc. Terms and Conditions