Fig. 2 Systemically released inflammatory factors directly affect HSC-e cell fate. Systemically released inflammatory factors directly affect HSC-e cell.

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Fig. 2 Systemically released inflammatory factors directly affect HSC-e cell fate. Systemically released inflammatory factors directly affect HSC-e cell fate. (A) Concentrations of human factors detected in the mouse serum after 14 days. Seven factors whose corresponding receptors were differentially expressed by HSCs are indicated as bold. (B) Forty Lin−CD34+CD38−CD45RA−CD49f+ cells were cultured in the serum-free control condition with the addition of each test factor. After 7 days, changes in the numbers of CD34+CD45RA−CD90+ (defined as HSC-e) and the remaining CD34+ (progenitor) and CD34− (differentiated) cells were calculated for each test condition against control. APC, allophycocyanin; FITC, fluorescein isothiocyanate; PE, phycoerythrin. (C) Average values of fold change in relation to control when interferon-inducible cytokine (IP-10) (orange), monocyte chemotactic protein 1 (MCP-1) (green), interferon-γ (IFNγ) (blue), and tumor necrosis factor–α (TNFα) (purple) were individually tested at three different doses (ng/ml) indicated by different shades for each factor. Two-tailed Kruskal-Wallis test and Mann-Whitney U test with Bonferroni correction (Padj = 0.983) were performed to compare each test condition to the control group. Data are from four or five independent experiments (n = 3 within each experiment). Two to five pooled UCB units were used per experiment. *P < 0.05; **P < 0.01; ***P < 0.001; and not significant (n.s.), P ≥ 0.05. Weijia Wang et al., Sci Transl Med 2017;9:eaag3214 Published by AAAS