Presentation is loading. Please wait.

Presentation is loading. Please wait.

Fig. 4 CXCL4 potentiates TLR8-mediated activation of SSc pDCs.

Published byRodger Wilson Modified over 5 years ago

Similar presentations

Presentation on theme: "Fig. 4 CXCL4 potentiates TLR8-mediated activation of SSc pDCs."— Presentation transcript:

1 Fig. 4 CXCL4 potentiates TLR8-mediated activation of SSc pDCs.
CXCL4 potentiates TLR8-mediated activation of SSc pDCs. (A and B) Purified pDCs from SSc patients (n = 8) were cultured in media alone (control), with ORN-8L (200 μg/ml), or with ORN-8L and CXCL4 (10 μg/ml) for 24 hours, and (A) IFN-α and IP-10 or (B) IL-6 and TNF were quantified in the supernatants by ELISA. Values were normalized to ORN-8L alone and represented as means ± SEM. (C to E) Purified pDCs from HDs were cultured alone, and purified pDCs from SSc patients were cultured for 24 hours either alone or in the presence of the PI3Kδ inhibitor CAL-101 (10 μM); (C) CXCL4, (D) IFN-α, or (E) IL-6 levels were quantified by ELISA. Results are normalized to 10,000 cells. All results are represented as means ± SEM, and statistical significance was evaluated using a Mann-Whitney U test. *P < 0.05, **P < 0.01, ***P < Marie Dominique Ah Kioon et al., Sci Transl Med 2018;10:eaam8458 Published by AAAS

Download ppt "Fig. 4 CXCL4 potentiates TLR8-mediated activation of SSc pDCs."

Similar presentations

Fig. 1 CSF1 is increased in blood of melanoma patients and correlates with disease progression. CSF1 is increased in blood of melanoma patients and correlates.

Fig. 1 CSF1 is increased in blood of melanoma patients and correlates with disease progression. CSF1 is increased in blood of melanoma patients and correlates.
Fig. 4. PVSRIPO infection of DCs is sublethal, is marginally productive, and induces sustained proinflammatory cytokine production. PVSRIPO infection of.

Fig. 4. PVSRIPO infection of DCs is sublethal, is marginally productive, and induces sustained proinflammatory cytokine production. PVSRIPO infection of.
Fig. 1. IL-6 is associated with resistance to EGFR TKIs and is induced by stress hormones. IL-6 is associated with resistance to EGFR TKIs and is induced.

Fig. 1. IL-6 is associated with resistance to EGFR TKIs and is induced by stress hormones. IL-6 is associated with resistance to EGFR TKIs and is induced.
Cytokine and chemokine expression of flucloxacillin-specific T cell clones (TCC) of patient P1. Cytokine and chemokine expression of flucloxacillin-specific.

Cytokine and chemokine expression of flucloxacillin-specific T cell clones (TCC) of patient P1. Cytokine and chemokine expression of flucloxacillin-specific.
Fig. 3. Cytokines trigger proliferation and block differentiation of perivascular adipocytes. Cytokines trigger proliferation and block differentiation.

Fig. 3. Cytokines trigger proliferation and block differentiation of perivascular adipocytes. Cytokines trigger proliferation and block differentiation.
Fig. 2. Pharmacologic inhibition of ALK impairs STING activation.

Fig. 2. Pharmacologic inhibition of ALK impairs STING activation.
Fig. 2. Mechanism of PD-L1 down-regulation in NOD HSPCs.

Fig. 2. Mechanism of PD-L1 down-regulation in NOD HSPCs.
Fig. 5 Maraba induces antitumor T cell immunity.

Fig. 5 Maraba induces antitumor T cell immunity.
Fig. 1 Localized treatment of TNBC cancers kills tumor cells and minimizes the metastatic burden. Localized treatment of TNBC cancers kills tumor cells.

Fig. 1 Localized treatment of TNBC cancers kills tumor cells and minimizes the metastatic burden. Localized treatment of TNBC cancers kills tumor cells.
Fig. 2 TLR8 is aberrantly expressed on pDCs from SSc patients.

Fig. 2 TLR8 is aberrantly expressed on pDCs from SSc patients.
Fig. 6 Bimodal treatment results in reduced tinnitus loudness and reduced TFI scores in human patients. Bimodal treatment results in reduced tinnitus loudness.

Fig. 6 Bimodal treatment results in reduced tinnitus loudness and reduced TFI scores in human patients. Bimodal treatment results in reduced tinnitus loudness.
PVSRIPO-mediated APC activation occurs in immunosuppressive conditions

PVSRIPO-mediated APC activation occurs in immunosuppressive conditions
Fig. 1 pDCs infiltrate the skin of SSc patients and spontaneously secrete IFN-α and CXCL4. pDCs infiltrate the skin of SSc patients and spontaneously secrete.

Fig. 1 pDCs infiltrate the skin of SSc patients and spontaneously secrete IFN-α and CXCL4. pDCs infiltrate the skin of SSc patients and spontaneously secrete.
Fig. 3 TLR8 signaling induces CXCL4 and IFN-α secretion by SSc PDCs.

Fig. 3 TLR8 signaling induces CXCL4 and IFN-α secretion by SSc PDCs.
Fig. 7. The PD-L1 defect is evident in HSPCs from T1D patients.

Fig. 7. The PD-L1 defect is evident in HSPCs from T1D patients.
Bio-AMS enhances the activity of rifampicin and ethambutol in vitro

Bio-AMS enhances the activity of rifampicin and ethambutol in vitro
Expression of CD36 and psap in a TMA of human ovarian cancer patients

Expression of CD36 and psap in a TMA of human ovarian cancer patients
Fig. 4 Expression of cleaved caspase 3, PD-L1, and PD-1 in HGGs after reovirus treatment. Expression of cleaved caspase 3, PD-L1, and PD-1 in HGGs after.

Fig. 4 Expression of cleaved caspase 3, PD-L1, and PD-1 in HGGs after reovirus treatment. Expression of cleaved caspase 3, PD-L1, and PD-1 in HGGs after.
Fig. 3. Wisper controls CF behavior and survival.

Fig. 3. Wisper controls CF behavior and survival.
Fig. 2 Systemically released inflammatory factors directly affect HSC-e cell fate. Systemically released inflammatory factors directly affect HSC-e cell.

Fig. 2 Systemically released inflammatory factors directly affect HSC-e cell fate. Systemically released inflammatory factors directly affect HSC-e cell.

Similar presentations

Ads by Google