Unraveling the Pros and Cons of Interferon-γ Gene Regulation

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Unraveling the Pros and Cons of Interferon-γ Gene Regulation Howard A. Young Immunity Volume 24, Issue 5, Pages 506-507 (May 2006) DOI: 10.1016/j.immuni.2006.05.004 Copyright © 2006 Elsevier Inc. Terms and Conditions

Figure 1 Schematic Representation of the Differential Effects of IL-12, IL-18, and TGF-β on Expression of IFN-γ by NK Cells IL-12 and IL-18 treatment downregulates the ability of NK cells to respond to TGF-β through downregulation of one chain of the TGF-β receptor and the TGF-β-activated transcription factors SMAD2 and SMAD3. In contrast, TGF-β downregulates IFN-γ expression though inhibition of the transcription factor T-bet and direct interaction of the SMAD proteins with the IFN-γ promoter. Immunity 2006 24, 506-507DOI: (10.1016/j.immuni.2006.05.004) Copyright © 2006 Elsevier Inc. Terms and Conditions