Bioinformatics Vicki & Joe.

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Presentation transcript:

Bioinformatics Vicki & Joe

Goals and Project Plan Better Understand Human Genome Project Computer Science and Molecular Biology Bioinformatics Data Usage Human Genome Project -identify all genes in human DNA -determine sequence of base pairs -store information in databases -improve tools for data analsys Computer Science and Molecular Biology -Find More links to Molecular Biology other than the basic definition of Bioinformatics -We know they exist - Pharmacutical industry and Gene Therapy Bioinformatics Data Usage -Understand what the data is used for after it is collected and cataloged into databases

Program Description Input: DNA Sequence Searches Sequence: Base Pairs Potential Gene Pseudogene Output: Potential Gene Search BLAST Database Program Searches for sequences of Base Pairs Order Matters: Starting Block: ATG Ending Block: Potential Gene: - Greater Than 300 Pseudogene: -Less Than 300 BLAST: -Defined Later

Main Concepts Bioinformatics DNA -> RNA-> Protein Replication -> Transcription -> Translation Sequence Alignment BLAST Bioinformatics is the field of science in which biology, computer science, and information technology merge to form a single discipline. The ultimate goal of the field is to enable the discovery of new biological insights as well as to create a global perspective from which unifying principles in biology can be discerned. DNA -deoxyribonucleic acid, is the hereditary material in humans and almost all other organisms. Nearly every cell in a person’s body has the same DNA -Information stored as a code made up of four chemical bases: adenine (A), guanine (G), cytosine (C), and thymine (T). (Our Program Searches DNA using these Bases -The order of these bases determines the organisms make up. -Every Cell Contains DNA RNA -Made up of chemical bases -thymine(T) replaced by cytosine -Is a copy of half the DNA strand (Transcription) -Used to transport Information outside of cell for cell replication Protein- -Proteins perform important tasks for the cell functions or serve as building blocks. -The flow of information from the genes determines the protein composition -and thereby the functions of the cell. Replication – -Process of Copying DNA Sequence Translation- -Process of building protiens using RNA Sequence Alignment- of arranging the sequences of DNA, RNA, or protein to identify regions of similarity that may be a consequence of functional, structural, or evolutionary relationships between the sequences BLAST- -compares translational products of the nucleotide query sequence to a protein database -This information is used to determine if there are and sequence alignments

References DNA-RNA-Protein Nobelprize.org Genetic Home Reference ghr.nlm.nih.gov A Science Primer ncbi.nlm.nih.gov Computer science and bioinformatics Communications of the ACM Volume 48 , Issue 3 (March 2005)