Homograft Implantation Techniques in the Aortic Position: To Preserve or Replace the Aortic Root? Thanos Athanasiou, MD, PhD, Catherine Jones, MBBS,

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Homograft Implantation Techniques in the Aortic Position: To Preserve or Replace the Aortic Root? Thanos Athanasiou, MD, PhD, Catherine Jones, MBBS, Ruyun Jin, MD, Gary L. Grunkemeier, PhD, Donald N. Ross, FRCS The Annals of Thoracic Surgery Volume 81, Issue 5, Pages 1578-1585 (May 2006) DOI: 10.1016/j.athoracsur.2005.12.049 Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Meta-analysis of early mortality for studies of homograft implantation in the aortic position comparing root replacement (RR) versus root preserving (RP) techniques. In the lower part, the dots and the solid lines are odds ratios of the fixed-effect model; the square and the dash lines are odds ratio of the random-effect model. (CI = confidence interval; SCT = subcoronary technique.) The Annals of Thoracic Surgery 2006 81, 1578-1585DOI: (10.1016/j.athoracsur.2005.12.049) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Begg’s funnel plot with pseudo 95% confidence limits of early mortality. The circles are proportional to the study size. (SE = standard error.) The Annals of Thoracic Surgery 2006 81, 1578-1585DOI: (10.1016/j.athoracsur.2005.12.049) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Egger’s publication bias plot of early mortality. (CI = confidence interval; OR = odds ratio; SE = standard error.) The Annals of Thoracic Surgery 2006 81, 1578-1585DOI: (10.1016/j.athoracsur.2005.12.049) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Cumulative and influential meta-analysis of early mortality for studies of homograft implantation in the aortic position comparing root replacement versus root preserving techniques. The black solid lines are the border of the 95% confidence interval (CI) for fixed-effect model and the dashed lines are for random-effect model. The Annals of Thoracic Surgery 2006 81, 1578-1585DOI: (10.1016/j.athoracsur.2005.12.049) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

Fig 5 Meta-analysis of reoperation for studies of homograft implantation in the aortic position comparing root replacement (RR) versus root preserving (RP) techniques. In the lower part, the dots and the solid lines are hazard ratios of fixed-effect model; the square and the dash lines are hazard ratios of random-effect model. (CI = confidence interval; SCT = subcoronary technique.) The Annals of Thoracic Surgery 2006 81, 1578-1585DOI: (10.1016/j.athoracsur.2005.12.049) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

Fig 6 Begg’s funnel plot with pseudo 95% confidence limits of reoperation. The circles are proportional to the study size. (SE = standard error.) The Annals of Thoracic Surgery 2006 81, 1578-1585DOI: (10.1016/j.athoracsur.2005.12.049) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

Fig 7 Egger’s publication bias plot of reoperation for studies of homograft implantation in the aortic position comparing root replacement versus root preserving techniques. (CI = confidence interval; HR = hazard ratio; SE = standard error.) The Annals of Thoracic Surgery 2006 81, 1578-1585DOI: (10.1016/j.athoracsur.2005.12.049) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

Fig 8 Cumulative and influential meta-analysis of reoperation for studies of homograft implantation in the aortic position comparing root replacement versus root preserving techniques. The black solid lines are the borders of the 95% confidence interval (CI) for the fixed-effect model and the dashed lines are for the random-effect model. The Annals of Thoracic Surgery 2006 81, 1578-1585DOI: (10.1016/j.athoracsur.2005.12.049) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions