Effects of donor bone marrow infusion in clinical lung transplantation

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S2 Fig. Phenotype of donor cells in the spleen and bone marrow of male mice. Splenocytes and bone marrow were isolated from male donor mice and stained.

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Effects of donor bone marrow infusion in clinical lung transplantation Si M Pham, MD, Abdul S Rao, MD, DPhil, Adriana Zeevi, PhD, Kenneth R McCurry, MD, Robert J Keenan, MD, J.David Vega, MD, Robert L Kormos, MD, Brack G Hattler, MD, PhD, John J Fung, MD, PhD, Thomas E Starzl, MD, PhD, Bartley P Griffith, MD The Annals of Thoracic Surgery Volume 69, Issue 2, Pages 345-350 (February 2000) DOI: 10.1016/S0003-4975(99)01471-X

Fig 1 Donor chimerism in the peripheral blood leukocytes of a lung recipients who received bone marrow infusion. Recipient cells were stained with a primary mouse antibody against human MHC class I, then counterstained with fluorescein isothiocyanate (FITC) conjugated goat anti-mouse secondary antibody, and analyzed using an EPICS Elite Flow Cytometer (Coulter Corp, Hialeah, FL). (A) Before transplantation; (B) 1 month, (C) 6 months, and (D) and 9 months after transplantation. The number in the right lower quadrant indicates the percentage of donor cells. The level of chimerism was higher after transplantation, but dwindled with time. The Annals of Thoracic Surgery 2000 69, 345-350DOI: (10.1016/S0003-4975(99)01471-X)

Fig 2 Donor cell chimerism detected by flow cytometry in lung recipients. Each circle represents 1 patient. Level below 0.5% is considered not quantifiable. The Annals of Thoracic Surgery 2000 69, 345-350DOI: (10.1016/S0003-4975(99)01471-X)

Fig 3 Mixed lymphocyte response demonstrating donor-specific hyporesponsiveness lung recipient who received donor bone marrow infusion. Freshly isolated recipient peripheral blood leukocytes were used as responders, while γ-irradiated donor splenocytes and third-party cells were used as stimulators. The response to donor stimulators was lowered than that to third-party stimulators. Numbers in parentheses indicate the level of chimerism (by flow cytometry). The Annals of Thoracic Surgery 2000 69, 345-350DOI: (10.1016/S0003-4975(99)01471-X)