Presentation is loading. Please wait.

Presentation is loading. Please wait.

Isolated tumor cells in bone marrow predict reduced survival in node-negative non-small cell lung cancer  Bernward Passlick, MD, Boris Kubuschok, MD,

Published byClarence Day Modified over 4 years ago

Similar presentations

Presentation on theme: "Isolated tumor cells in bone marrow predict reduced survival in node-negative non-small cell lung cancer  Bernward Passlick, MD, Boris Kubuschok, MD,"— Presentation transcript:

1 Isolated tumor cells in bone marrow predict reduced survival in node-negative non-small cell lung cancer  Bernward Passlick, MD, Boris Kubuschok, MD, Jakob R Izbicki, MD, Olaf Thetter, MD, Klaus Pantel, MD  The Annals of Thoracic Surgery  Volume 68, Issue 6, Pages (December 1999) DOI: /S (99)01125-X

2 Fig 1 Isolated CK18+ cell in the bone marrow of a patient with a resectable NSCLC (adenocarcinoma; pT1, pN0, M0). Alkaline phosphate-anti-alkaline phosphatase (APAAP) staining using monoclonal antibody CK2 against CK18; in order to facilitate the detection of immunocytochemical positive cells, no counter staining was done. The Annals of Thoracic Surgery  , DOI: ( /S (99)01125-X)

3 Fig 2 Frequency of CK18+ tumor cells in bone marrow of patients with completely resected NSCLC. The Annals of Thoracic Surgery  , DOI: ( /S (99)01125-X)

4 Fig 3 Overall survival (Kaplan-Meier analysis) in pN0 patients (n = 66) with surgically resected NSCLC depending on the presence (thick line) or absence (thin line) of immunocytochemically CK18+ tumor cells (≥ 2 cells per 4 × 105) in bone marrow. The difference is significant: p = by log-rank test. The Annals of Thoracic Surgery  , DOI: ( /S (99)01125-X)

Download ppt "Isolated tumor cells in bone marrow predict reduced survival in node-negative non-small cell lung cancer  Bernward Passlick, MD, Boris Kubuschok, MD,"

Similar presentations

G.Liguori,G.Pirozzi^, I. Forte, G.Botti, R.Franco, A.La Rocca*, G.Rocco* Istituto Nazionale Tumori Napoli Dip.Anatomia Patologica; Dip.Onc.Sperimentale^;

G.Liguori,G.Pirozzi^, I. Forte, G.Botti, R.Franco, A.La Rocca*, G.Rocco* Istituto Nazionale Tumori Napoli Dip.Anatomia Patologica; Dip.Onc.Sperimentale^;
Results of surgical treatment of adenocarcinoma of the gastric cardia

Results of surgical treatment of adenocarcinoma of the gastric cardia
Non–Small Cell Lung Cancer at the Extremes of Age: Impact on Diagnosis and Treatment  William C Nugent, MD, Mark T Edney, BA, Paul G Hammerness, BA, Bradley.

Non–Small Cell Lung Cancer at the Extremes of Age: Impact on Diagnosis and Treatment  William C Nugent, MD, Mark T Edney, BA, Paul G Hammerness, BA, Bradley.
Elizabeth A. David, MD, David T

Elizabeth A. David, MD, David T
Jeffrey L. Port, MD, Robert J. Korst, MD, Paul C. Lee, MD, Amanda L

Jeffrey L. Port, MD, Robert J. Korst, MD, Paul C. Lee, MD, Amanda L
Definitive or Preoperative Chemoradiation Therapy for Esophageal Cancer: Patterns of Care and Survival Outcomes  Meng S. Shao, MD, Andrew T. Wong, MD,

Definitive or Preoperative Chemoradiation Therapy for Esophageal Cancer: Patterns of Care and Survival Outcomes  Meng S. Shao, MD, Andrew T. Wong, MD,
Michael F. Nentwich, MD, Benjamin A. Bohn, MD, Faik G

Michael F. Nentwich, MD, Benjamin A. Bohn, MD, Faik G
Survival After Surgical Resection for Lung Cancer in Patients With Chronic Obstructive Pulmonary Disease  Anders Bugge, MD, May Brit Lund, MD, PhD, Cathrine.

Survival After Surgical Resection for Lung Cancer in Patients With Chronic Obstructive Pulmonary Disease  Anders Bugge, MD, May Brit Lund, MD, PhD, Cathrine.
Primary non-Hodgkin’s lymphoma of the lung

Primary non-Hodgkin’s lymphoma of the lung
Melanie Subramanian, MD, Timothy McMurry, PhD, Bryan F

Melanie Subramanian, MD, Timothy McMurry, PhD, Bryan F
Rodrigo A. S. Sardenberg, MD, Clovis Pinto, MD, Cynthia A

Rodrigo A. S. Sardenberg, MD, Clovis Pinto, MD, Cynthia A
Chun Chieh Lin, PhD, MBA, Matthew P

Chun Chieh Lin, PhD, MBA, Matthew P
Prognostic Significance of TAZ Expression in Resected Non-Small Cell Lung Cancer  Mian Xie, MD, PhD, Li Zhang, MD, Chao-Sheng He, MD, Jin-Hui Hou, MD,

Prognostic Significance of TAZ Expression in Resected Non-Small Cell Lung Cancer  Mian Xie, MD, PhD, Li Zhang, MD, Chao-Sheng He, MD, Jin-Hui Hou, MD,
Elliot Wakeam, MD, MPH, Meredith Giuliani, MBBS, MEd, Natasha B

Elliot Wakeam, MD, MPH, Meredith Giuliani, MBBS, MEd, Natasha B
Tumor Necrosis as a Prognostic Factor for Stage IA Non-Small Cell Lung Cancer  Seong Yong Park, MD, Hyun-Sung Lee, MD, PhD, Hee-Jin Jang, MD, Geon Kook.

Tumor Necrosis as a Prognostic Factor for Stage IA Non-Small Cell Lung Cancer  Seong Yong Park, MD, Hyun-Sung Lee, MD, PhD, Hee-Jin Jang, MD, Geon Kook.
Significance of P53 and Rb protein expression in surgically treated non-small cell lung cancers  Yung-Chie Lee, MD, PhD, Yih-Leong Chang, MD, Shi-Ping.

Significance of P53 and Rb protein expression in surgically treated non-small cell lung cancers  Yung-Chie Lee, MD, PhD, Yih-Leong Chang, MD, Shi-Ping.
Matthew D. Taylor, MD, Alykhan S. Nagji, MD, Castigliano M

Matthew D. Taylor, MD, Alykhan S. Nagji, MD, Castigliano M
Lisa M. Brown, MD, MAS, David T. Cooke, MD, Elizabeth A. David, MD 

Lisa M. Brown, MD, MAS, David T. Cooke, MD, Elizabeth A. David, MD 
Surgical Results and Prognostic Factors in Early Non–Small Cell Lung Cancer  José Padilla, MD, Vı́ctor Calvo, MD, Juan C Peñalver, MD, Gabriel Sales, MD,

Surgical Results and Prognostic Factors in Early Non–Small Cell Lung Cancer  José Padilla, MD, Vı́ctor Calvo, MD, Juan C Peñalver, MD, Gabriel Sales, MD,
Long-Term Outcomes of En Bloc Resection of Non-Small Cell Lung Cancer Invading the Thoracic Inlet and Spine  Elie Fadel, MD, Gilles Missenard, MD, Charles.

Long-Term Outcomes of En Bloc Resection of Non-Small Cell Lung Cancer Invading the Thoracic Inlet and Spine  Elie Fadel, MD, Gilles Missenard, MD, Charles.

Similar presentations

Ads by Google