Estrogen enhances immunoglobulin production by human PBMCs

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Estrogen enhances immunoglobulin production by human PBMCs Naoko Kanda, MD, PhD, Kunihiko Tamaki, MD, PhD Journal of Allergy and Clinical Immunology Volume 103, Issue 2, Pages 282-288 (February 1999) DOI: 10.1016/S0091-6749(99)70503-8 Copyright © 1999 Mosby, Inc. Terms and Conditions

Fig. 1 Dose dependency of the stimulatory effect of E2 on spontaneous immunoglobulin production by human PBMCs. PBMCs (2 × 105 cells/200 μL/well) were cultured in triplicate for 7 days in the presence or absence of indicated doses of E2 , 17α-estradiol, estrone, or estriol. Culture supernatants were analyzed for IgG (A) and IgM (B) by ELISA. Data are means ± SD of triplicate cultures of PBMCs from one man and represent 6 separate experiments with PBMCs from 6 different donors (3 men and 3 women). *P < .01 versus control cultures. Journal of Allergy and Clinical Immunology 1999 103, 282-288DOI: (10.1016/S0091-6749(99)70503-8) Copyright © 1999 Mosby, Inc. Terms and Conditions

Fig. 2 Effect of E2 on spontaneous IgG (A) and IgM (B) production by human PBMCs. PBMCs (2 × 105 cells/200 μL/well) from 6 men and 7 women were cultured for 7 days with medium alone, with 17α-estradiol, or with E2 (each 10–8 mol/L). Each point (open circles) represents mean of immunoglobulin amounts produced in triplicate cultures from individual donors. SDs of triplicate cultures were less than 10% of means. Corresponding values for each donor are connected by a solid line. Group means are also displayed (filled circles), and corresponding values are connected by a broken line. Journal of Allergy and Clinical Immunology 1999 103, 282-288DOI: (10.1016/S0091-6749(99)70503-8) Copyright © 1999 Mosby, Inc. Terms and Conditions

Fig. 3 Inhibition by anticytokine antibodies of E2 induced increase in immunoglobulin production by human PBMCs. PBMCs (2 × 105 cells/200 μL/well) were cultured in triplicate for 7 days with medium alone, with 17α-estradiol, or with E2 (each 10–8 mol/L) in the presence or absence of various antibodies (each 10 μg/mL). IgG (A) and IgM (B) production were measured in each culture as described in the legend for Fig 1. Concentration of antibodies was determined as recommended by the manufacturers. Data are means ± SD (n = 13, 6 men and 7 women). SDs of triplicate cultures from individual donors were less than 10% of the means. *P < .0001 versus control cultures with medium alone. †P < .0001 versus cultures with E2 alone. Journal of Allergy and Clinical Immunology 1999 103, 282-288DOI: (10.1016/S0091-6749(99)70503-8) Copyright © 1999 Mosby, Inc. Terms and Conditions

Fig. 4 Effect of E2 on IL-10 production by human monocytes, T cells, and B cells. Monocytes, T cells, and B cells (2 × 105 cells/200 μL/well) were cultured in triplicate for 24 hours in the presence or absence of indicated doses of E2 or 17α-estradiol, and the culture supernatants were analyzed for IL-10 by ELISA. Data are means ± SD of triplicate cultures of PBMC fractions from one man and represent 4 separate experiments with PBMC fractions from 4 different donors (2 men and 2 women). *P < .001 versus control cultures. Journal of Allergy and Clinical Immunology 1999 103, 282-288DOI: (10.1016/S0091-6749(99)70503-8) Copyright © 1999 Mosby, Inc. Terms and Conditions