Rare cells predict GVHD

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Rare cells predict GVHD by Samuel Strober, and Robert Lowsky Blood Volume 119(21):4820-4821 May 24, 2012 ©2012 by American Society of Hematology

Donor natural killer (NK) T cells in hematopoietic cell transplants suppress graft-versus-host disease (GVHD) that is induced by donor CD4+ and CD8+ conventional T (Tcon) cells. Donor natural killer (NK) T cells in hematopoietic cell transplants suppress graft-versus-host disease (GVHD) that is induced by donor CD4+ and CD8+ conventional T (Tcon) cells. The T-cell antigen receptors (TCR)s of the Tcon cells recognize class I and class II MHC receptors associated with peptides, and the NKT cells recognize CD1d receptors associated with glycolipids on the surface of antigen presenting cells (APCs). Professional illustration by Alice Y. Chen. Samuel Strober, and Robert Lowsky Blood 2012;119:4820-4821 ©2012 by American Society of Hematology