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Sarah Nikiforow, Haesook T

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1 Phase I Study of Alemtuzumab for Therapy of Steroid-Refractory Chronic Graft-versus- Host Disease 
Sarah Nikiforow, Haesook T. Kim, Bhavjot Bindra, Sean McDonough, Brett Glotzbecker, Philippe Armand, John Koreth, Vincent T. Ho, Edwin P. Alyea, Bruce R. Blazar, Jerome Ritz, Robert J. Soiffer, Joseph H. Antin, Corey S. Cutler  Biology of Blood and Marrow Transplantation  Volume 19, Issue 5, Pages (May 2013) DOI: /j.bbmt Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Kaplan-Meier curve: probability of survival versus months after alemtuzumab administration. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 Leukocyte and lymphocyte recovery after alemtuzumab administration. (A) Median total white blood cell (solid line) and leukocyte (dashed line) numbers for all assessable subjects at indicated time points. (B) Repopulation of lymphocyte subsets as reflected by median CD3+ T cell, CD20+ B cell, and CD56+CD3-NK cell concentrations among all assessable subjects at indicated time points. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions

4 Figure 3 T cell subset composition after alemtuzumab administration. (A) Normalized median CD4 and CD8 T cell percentages within the CD3+ T cell population among all assessable subjects. (B) Normalized median conventional T cells “Tcon” (CD3+CD4+CD25neg-lowCD127med-high) and regulatory T cells “Treg” (CD3+CD4+CD25med-highCD127low) percentages within the CD4+ T cell subset among all assessable subjects. (C and D) Normalized median percentages of CD45RO+CD62L– effector memory cells, CD45RO+CD62L+ central memory cells, CD45RO-CD62L– terminal effector cells, and CD45RO-CD62L+ naive cells in the CD4+ (C) and CD8+ (D) T cell subsets among all assessable subjects. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions


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