1. Chimeric antigen receptor–modified T cells: CD19 and the road beyond
by Alexander I. Salter, Margot J. Pont, and Stanley R. Riddell
Blood
Volume 131(24):
June 14, 2018
©2018 by American Society of Hematology

2. CAR design.
CAR design. (A) Schematic of TCR and costimulatory molecule expression on T cells. (B-C) Synthetic single-chain receptors designed to deliver modified signal 1 and signal 2 in an scFv/CD28/CD3ζ (B) or scFv/4-1BB/CD3ζ format (C).
Alexander I. Salter et al. Blood 2018;131:
©2018 by American Society of Hematology

3. CAR toolbox.
CAR toolbox. Toolbox of applications in synthetic biology that may extend and enhance the efficacy and safety of ACT.
Alexander I. Salter et al. Blood 2018;131:
©2018 by American Society of Hematology