Postnatal lethality, pleural effusion in endothelial-specific Piezo1 cKO mice. Postnatal lethality, pleural effusion in endothelial-specific Piezo1 cKO.

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Postnatal lethality, pleural effusion in endothelial-specific Piezo1 cKO mice. Postnatal lethality, pleural effusion in endothelial-specific Piezo1 cKO mice. (A) Survival rate of WT (n = 14), Het (Piezo1−/+ or Tie2Cre;Piezo1+/fl) (n = 13), or Tie2Cre;Piezo1cKO (n = 14) newborn mice. (B) Chylous pleural effusion (red arrow) observed in 1-wk-old Tie2Cre;Piezo1cKO, but not in WT littermate. (Scale bar: 5 mm.) (C) Amount of liquid in the chest cavity at P9. Mean ± SEM (n = 6 for WT, n = 5 for Tie2Cre;Piezo1cKO mice). *P < 0.05, unpaired t test. (D) Survival rate of WT (n = 13) or Lyve1Cre;Piezo1cKO (n = 15) newborn mice. (E) Chylous pleural effusion (red arrows) observed in 1-wk-old Lyve1Cre;Piezo1cKO mice, but not in WT littermate. (Scale bar: 5 mm.) (F) Amount of liquid in the chest cavity in 1-wk-old mice. Mean ± SEM (n = 16 for WT, n = 8 for Lyve1Cre;Piezo1cKO mice). *P < 0.05, unpaired t test. Keiko Nonomura et al. PNAS doi:10.1073/pnas.1817070115 ©2018 by National Academy of Sciences