Furosemide stimulates macula densa cyclooxygenase-2 expression in rats

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Furosemide stimulates macula densa cyclooxygenase-2 expression in rats Bianca Mann, Andrea Hartner, Boye L. Jensen, Martin Kammerl, Bernhard K. Krämer, Armin Kurtz Kidney International Volume 59, Issue 1, Pages 62-68 (January 2001) DOI: 10.1046/j.1523-1755.2001.00466.x Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 1 Effects of furosemide (12 mg/kg per day) and hydrochlorothiazide (HCT; 30 mg/kg per day) on urine production (A), hematocrit (B), and body weight gain (C) in rats. Data are means ± SEM of 18 vehicle-infused, 18 furosemide-infused, 6 vehicle-fed, and 6 HCT-fed animals. *P < 0.05 vs. respective control. Kidney International 2001 59, 62-68DOI: (10.1046/j.1523-1755.2001.00466.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 2 Plasma renin activity (A) and renal renin mRNA abundance (B) in vehicle-treated and in furosemide or hydrochlorothiazide (HCT)-treated infused rats. Data are means ± SEM. *P < 0.05 vs. respective control. Kidney International 2001 59, 62-68DOI: (10.1046/j.1523-1755.2001.00466.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 3 Cyclooxygenase (COX)-2 mRNA (A) and COX-1 mRNA (B) abundance in the renal cortex from vehicle-treated, furosemide, or HCT-treated rats. Data are means ± SEM. *P < 0.05 vs. respective control. Kidney International 2001 59, 62-68DOI: (10.1046/j.1523-1755.2001.00466.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 4 Distribution of COX-2 immunoreactivity in rat kidney cortex from a vehicle-infused rat (A) and a rat infused with furosemide (B; magnification ×100). (C) Localization of COX-2 immunoreactivity in the macula densa of a furosemide-infused rat (magnification ×400). Kidney International 2001 59, 62-68DOI: (10.1046/j.1523-1755.2001.00466.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 5 COX-2 immunoreactivity in the renal cortex of vehicle, furosemide, or HCT-treated rats. COX-2 immunoreactivity is given as COX-2 index, that is, the percentage cut glomeruli in a section displaying COX-2 immunoreactivity in the juxtaglomerular apparatus. Data are means ± SEM. *P < 0.05 vs. respective control. Kidney International 2001 59, 62-68DOI: (10.1046/j.1523-1755.2001.00466.x) Copyright © 2001 International Society of Nephrology Terms and Conditions