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20-HETE in acute kidney injury

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Presentation on theme: "20-HETE in acute kidney injury"— Presentation transcript:

1 20-HETE in acute kidney injury
Richard J. Roman, Talha Akbulut, Frank Park, Kevin R. Regner  Kidney International  Volume 79, Issue 1, Pages (January 2011) DOI: /ki Copyright © 2011 International Society of Nephrology Terms and Conditions

2 Figure 1 Contrasting effects of HET0016, 24h after 30min of bilateral renal IRI, or after acute uninephrectomy and 45min of IRI in the one remaining kidney of Sprague Dawley rats. The results obtained in the bilateral renal ischemia group were replotted from the study of Regner et al.,11 whereas the results following ischemia in the uninephrectomized rats are original. Asterisks indicate a significant difference in the plasma creatinine concentration measured in the animals treated with HET0016 (10mg/kg, subcutaneously) versus the corresponding values observed in the vehicle-treated animals. HET, HET0016; IRI, ischemia/reperfusion injury; Unx, uninephrectomized. Kidney International  , 10-13DOI: ( /ki ) Copyright © 2011 International Society of Nephrology Terms and Conditions


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