A Way to DAI Cell Host & Microbe

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Presentation transcript:

A Way to DAI Cell Host & Microbe Patrick-Simon Welz, Manolis Pasparakis Cell Host & Microbe Volume 11, Issue 3, Pages 223-225 (March 2012) DOI: 10.1016/j.chom.2012.02.003 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 RHIM-Dependent Association of DAI with RIP Kinases Activates Antiviral Responses DAI, presumably activated by sensing viral dsDNA, interacts with RIP3 to induce necrosis of viral infected cells. In addition, DAI associates with RIP1 to activate IKK/NF-κB signaling that synergizes with DAI-mediated TBK1/IRF activation to induce type I interferon expression. The viral inhibitor vIRA disrupts the RHIM-dependent interaction of DAI with RIP1 and RIP3, thereby preventing both NF-κB activation and virus-induced necrosis of infected cells. Cell Host & Microbe 2012 11, 223-225DOI: (10.1016/j.chom.2012.02.003) Copyright © 2012 Elsevier Inc. Terms and Conditions