SIBM: Epidemiology. sIBM: Epidemiology Disease Characteristics: Distinctive Patterns of Muscle Involvement.

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Presentation transcript:

sIBM: Epidemiology

Disease Characteristics: Distinctive Patterns of Muscle Involvement

Clinical Findings: Quadriceps Weakness and Wasting

Clinical Findings: Finger Flexion and Grip Weakness

Clinical Findings: Respiratory Muscle Weakness

sIBM: Disease Progression Over Time

Differential Diagnosis

Diagnostic Testing

Myositis-Specific Autoantibodies

Diagnostic Criteria

Pathological Features: Endomysial Inflammatory Infiltrates

Pathological Features: Invasion by Inflammatory Cells

Pathological Features: Rimmed Vacuoles

Pathological Features: Immunostaining

Pathogenesis Working Hypothesis: Inflammation  Degeneration

sIBM: Current Management Challenges

Causes of Death in Patients With sIBM

Conclusions

Abbreviations