GWLSs in a family with hereditary VUR

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GWLSs in a family with hereditary VUR GWLSs in a family with hereditary VUR. (A) Abbreviated pedigree of a 96-member kindred with hereditary VUR. There are at least nine affected individuals with imaging confirmation of VUR/duplex kidney. GWLSs in a family with hereditary VUR. (A) Abbreviated pedigree of a 96-member kindred with hereditary VUR. There are at least nine affected individuals with imaging confirmation of VUR/duplex kidney. Squares are male family members and circles are female family members. Obligate heterozygous individuals are shown in partially filled circle/rectangle. (B) Imaging from one of the affected individuals showing grade 4 VUR on the left side. DMSA scan from the same individual showed left renal parenchymal scarring. (C) Genome-wide linkage scan using the Illumina Infinum II HumanLinkage-24 genotyping beadchip assay yields multipoint LOD scores of 3.3 on chromosome 6p in the family. (D) Fine mapping of the chromosome 6p locus and haplotype of individuals defining the chromosome 6P minimal candidate region. Individual 1001 has the ancestral haplotype, the centromeric flanking marker D6S109 is defined by affected individual 1, and telomeric flanking marker D6S271 defined by affected individual 103. Rasheed A. Gbadegesin et al. JASN 2013;24:1313-1322 ©2013 by American Society of Nephrology