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Copyright © 2000 American Medical Association. All rights reserved.

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1 Copyright © 2000 American Medical Association. All rights reserved.
From: Hereditary Motor and Sensory Neuropathy Type 2C Is Genetically Distinct From Types 2B and 2D Arch Neurol. 2000;57(5): doi: /archneur Figure Legend: Multipoint linkage analysis with markers spanning chromosome 7p14. Ionasescu et al have shown that the hereditary motor and sensory neuropathy (HMSN) type 2D locus is just proximal to D7S435. Limit of detection (LOD) scores are shown on the y-axis and genetic distances (centimorgans [cM]) are shown on the x-axis. Distances between markers are based on maps from the Genome Data Base (accessed June 1999; The points with an LOD score of −2 are 9.7 cM proximal to D7S1801 and 10.1 cM distal to D7S435. No evidence supported mapping of the HMSN 2C gene to the studied region of chromosome 7. Abbreviation cen indicates centromere; p ter, p terminus. Date of download: 10/5/2017 Copyright © 2000 American Medical Association. All rights reserved.

2 Copyright © 2000 American Medical Association. All rights reserved.
From: Hereditary Motor and Sensory Neuropathy Type 2C Is Genetically Distinct From Types 2B and 2D Arch Neurol. 2000;57(5): doi: /archneur Figure Legend: Multipoint linkage analysis with markers spanning chromosome 3q13-q22. Limit of detection (LOD) scores are shown on the y-axis and genetic distances (centimorgans [cM]) are shown on the x-axis. Distances between markers are based on maps from the Cooperative Human Linkage Center and Généthon. The points with an LOD score of −2 are 20.7 cM proximal to D3S1558 and 27.8 cM distal to D3S1744. No evidence mapping the HMSN 2C gene to the studied region of chromosome 3 was found. Abbreviation q ter indicates q terminus; cen, centromere. Date of download: 10/5/2017 Copyright © 2000 American Medical Association. All rights reserved.

3 Copyright © 2000 American Medical Association. All rights reserved.
From: Hereditary Motor and Sensory Neuropathy Type 2C Is Genetically Distinct From Types 2B and 2D Arch Neurol. 2000;57(5): doi: /archneur Figure Legend: Pedigree of the kindred with hereditary motor and sensory neuropathy type 2C in the present study. Squares represent male subjects; circles, female; black and white symbols, affected by history; solid black symbols, affected by clinical examination; white symbols, unaffected; plus sign, genotype checked; and diagonal slash, deceased. Numbering used is the same as in our previous publication. Date of download: 10/5/2017 Copyright © 2000 American Medical Association. All rights reserved.


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