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A New Familial Amyotrophic Lateral Sclerosis Locus on Chromosome 16q12

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Presentation on theme: "A New Familial Amyotrophic Lateral Sclerosis Locus on Chromosome 16q12"— Presentation transcript:

1 A New Familial Amyotrophic Lateral Sclerosis Locus on Chromosome 16q12
A New Familial Amyotrophic Lateral Sclerosis Locus on Chromosome 16q q12.2  Halah Abalkhail, John Mitchell, James Habgood, Richard Orrell, Jacqueline de Belleroche  The American Journal of Human Genetics  Volume 73, Issue 2, Pages (August 2003) DOI: /377156 Copyright © 2003 The American Society of Human Genetics Terms and Conditions

2 Figure 1 Haplotype analysis of the chromosome 16q q13.1 region in the family with FALS. Allele data for 11 markers in this region are shown; inferred genotypes of the reconstructed individuals 3.10, 3.11, 4.5, and 4.7 are indicated by italics. The names of the makers are listed on the far left side of each generation. Haplotypes associated with the disease are indicated by thick solid “boxing.” Crossover events are indicated by a change in the “boxing.” Both males and females are indicated by a diamond symbol, affected individuals are represented by a solid black diamond, and individuals of unconfirmed status with a light gray diamond. The index case is 5.10. The American Journal of Human Genetics  , DOI: ( /377156) Copyright © 2003 The American Society of Human Genetics Terms and Conditions

3 Figure 2 Multipoint linkage analysis of chromosome 16, generated by use of the SIMWALK2 version 2.82 software package The American Journal of Human Genetics  , DOI: ( /377156) Copyright © 2003 The American Society of Human Genetics Terms and Conditions

4 Figure 3 A genome screen of family MB2 for chromosomes 1–15 and 17–22, by use of a total of 301 microsatellite markers. The multipoint linkage analysis was performed by use of Genehunter version 2.1r3 software. The numbers of microsatellite markers for each chromosome were 18, 18, 9, 18, 11, 52, 18, 17, 8, 7, 14, 33, 7, 11, 10, 12, 11, 4, 9, 9, and 5, respectively. The American Journal of Human Genetics  , DOI: ( /377156) Copyright © 2003 The American Society of Human Genetics Terms and Conditions


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