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Volume 78, Issue 2, Pages 127-129 (July 2010) The nanopeptide hormone vasopressin is a new player in the modulation of renal Na+– Cl− cotransporter activity Gerardo Gamba Kidney International Volume 78, Issue 2, Pages 127-129 (July 2010) DOI: 10.1038/ki.2010.147 Copyright © 2010 International Society of Nephrology Terms and Conditions

Figure 1 Known vasopressin actions in the nephron. Vasopressin is well known for its activation properties in renal tubules via its interaction with the V2-type receptor, particularly in the thick ascending limb of Henle (TAL) and collecting duct (CD). Pedersen et al.8 show that vasopressin is also an activator of the Na+–Cl− cotransporter (NCC) in the distal convoluted tubule (DCT). (a) The DCT in the absence of vasopressin. (b) The DCT in the presence of vasopressin. Kidney International 2010 78, 127-129DOI: (10.1038/ki.2010.147) Copyright © 2010 International Society of Nephrology Terms and Conditions