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Molecular biology of distal nephron sodium transport mechanisms

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1 Molecular biology of distal nephron sodium transport mechanisms
Gerardo Gamba  Kidney International  Volume 56, Issue 4, Pages (October 1999) DOI: /j x Copyright © 1999 International Society of Nephrology Terms and Conditions

2 Figure 1 (A) Physiology of sodium reabsorption in the thick ascending limb. (B) Predicted topology of the bumetanide-sensitive Na+:K+:2 Cl- cotransporter (BSC1). Abbreviations: ATP, adenosine triphosphate; ADH, antidiuretic hormone; cAMP, cyclic AMP; PKA, protein kinase A (▪); PKC, protein kinase C (•). Kidney International  , DOI: ( /j x) Copyright © 1999 International Society of Nephrology Terms and Conditions

3 Figure 2 Predicted topology of the six alternatively splicing isoforms of BSC1 in mouse kidney. Domains encoded by the mutually exclusive cassette exons B, A, and F are shown in white, black and gray, respectively. Black dots and boxes represent putative PKC and PKA sites, respectively. Kidney International  , DOI: ( /j x) Copyright © 1999 International Society of Nephrology Terms and Conditions

4 Figure 3 (A) Physiology of sodium reabsorption in the distal convoluted tubule. (B) Predicted topology of the thiazide-sensitive Na+:Cl- cotransporter (TSC1). Abbreviations are: PKA, protein kinase A (▪); PKC, protein kinase C (•). Kidney International  , DOI: ( /j x) Copyright © 1999 International Society of Nephrology Terms and Conditions

5 Figure 4 (A) Phylogenetic tree of the cation-chloride coupled cotransporter gene family. (B) Diagram showing percentage of homology among members of the cation-chloride gene family. Kidney International  , DOI: ( /j x) Copyright © 1999 International Society of Nephrology Terms and Conditions

6 Figure 5 (A) Physiology of sodium reabsorption in the principal cells of the collecting duct. (B) Linear representation of the epithelial Na+ channel (ENaC) α, β; and γ subunits. Black boxes represent the predicted membrane spanning domains and gray boxes the cystine-rich segment of the extracellular loop. Kidney International  , DOI: ( /j x) Copyright © 1999 International Society of Nephrology Terms and Conditions

7 Figure 6 (A) Phylogenetic tree of the superfamily of amiloride-sensitive cation channels. (B) Diagram showing percentage of homology among the four known subunits of the epithelial Na+ channels (ENaC). Kidney International  , DOI: ( /j x) Copyright © 1999 International Society of Nephrology Terms and Conditions

8 Kidney International 1999 56, 1606-1622DOI: (10. 1046/j. 1523-1755
Kidney International  , DOI: ( /j x) Copyright © 1999 International Society of Nephrology Terms and Conditions


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