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Mineralocorticoid selectivity: Molecular and cellular aspects

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1 Mineralocorticoid selectivity: Molecular and cellular aspects
Dr Nicolette Farman, Brigitte Bocchi  Kidney International  Volume 57, Issue 4, Pages (April 2000) DOI: /j x Copyright © 2000 International Society of Nephrology Terms and Conditions

2 Figure 1 Corticosteroid hormones, their plasma levels, affinity for mineralocorticoid receptors (MR) and glucocorticoid receptors (GR), and the number of receptors per aldosterone renal target cell. Kidney International  , DOI: ( /j x) Copyright © 2000 International Society of Nephrology Terms and Conditions

3 Figure 2 Schematic representation of mineralocorticoid receptors (MR), glucocorticoid receptors (GR), and 11β-hydroxysteroid dehydrogenase-2 (HSD2) expression along the mammalian nephron. The black zone represents the sites of high expression of GR, HSD2 (in rabbit, mouse, and humans), and MR [in rabbit; in the rat, the cortical portion of Henle's loop (tal) also expresses high levels of MR and HSD2]. Abbreviations are: pt, proximal tubule; dct, distal tubule; cd, collecting duct. Kidney International  , DOI: ( /j x) Copyright © 2000 International Society of Nephrology Terms and Conditions


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