Overview Bioinformatics: Analyzing biological data using statistics, math modeling, and computer science BLAST = Basic Local Alignment Search Tool Input.

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Presentation transcript:

Investigation 3: Comparing DNA Sequences to Understand Evolutionary Relationships

Overview Bioinformatics: Analyzing biological data using statistics, math modeling, and computer science BLAST = Basic Local Alignment Search Tool Input gene sequence of interest and search genomic libraries for identical or similar sequences This lab: Use BLAST to compare several genes and use information to construct a cladogram

NCBI Blast Tutorial

Our Investigation Fossil specimen discovered in Liaoning Province, China Possibly a new species Normally, soft tissue does not survive fossilization, but scientists were able to extract DNA from this fossil Several genes were sequenced Use BLAST to analyze genes and determine evolutionary history of fossil specimen

Where do you think does this fossil should be placed?

Lab Protocol Follow lab instruction guide (found on Schoology) Read the lab manual (red book) for step-by-step instructions All observations and data entered into your lab notebook Timing: Pre-Lab Tasks: 15 minutes Lab (using computers): 30 minutes

Cladogram (with shared derived traits indicated on diagram)

Phylogenetic Tree