H&E staining reveals defects in the CNS of Gpr124−/− mice.

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Presentation transcript:

H&E staining reveals defects in the CNS of Gpr124−/− mice. H&E staining reveals defects in the CNS of Gpr124−/− mice. (A) E13.5 Gpr124−/− H&E-stained brain coronal sections showing bilateral hemorrhage in the pallium (P) extending into the ganglionic eminence (GE). V, lateral ventricle. (B) Hemorrhage, hypoplasia, and limited distinction between the lateral and medial lobes of the ganglionic eminence at E12.5. (C) Loose attachment of glomeruloids to the underlying neuroepithelium at E13.5. (Scale bar, 100 μm.)‏ Mike Cullen et al. PNAS 2011;108:14:5759-5764 ©2011 by National Academy of Sciences