Selecting NOACs for High-Risk Patients

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Presentation transcript:

Selecting NOACs for High-Risk Patients

Program Goals

Benefit of NOACs in High-Risk Patients Meta-Analysis of Phase 3 SPAF Trial Subgroups

Similar Risk Factors Predicting the Risk of Thromboembolism and Bleeding in Patients With AF

Antithrombotic Treatment Based on Stroke Risk Findings From GLORIA-AF Registry

Recommendations for Stroke Prevention in Patients With AF

Global Differences in Antithrombotic Treatment Findings From GLORIA-AF Registry

Evolution of Baseline Antithrombotic Treatment: Sequential Cohorts of GARFIELD-AF Registry

Increasing Use of VKA With Increasing Risk for Stroke Insights From the GARFIELD-AF Registry

Patient Case Managing Patients With a Prior Event

Initiation of OAC Therapy After Stroke

Patients With AF and Prior Stroke or TIA NOAC vs VKA Meta-Analysis

Cancer in Patients at Risk for Thrombosis

Cancer in Patients With AF

Hokusai VTE-Cancer Clinical Outcomes in Patients With Cancer at Risk for VTE

Patient Case High Risk of Bleeding

Patients With AF and High Risk of Bleeding

NOAC Meta-Analysis in Secondary Stroke Prevention

Valvular Atrial Fibrillation and Bioprosthetic Heart Valves

Mechanical Heart Valves Dabigatran vs VKA in the RE-ALIGN Study

NOACs in Patients With AF and Valvular Heart Disease Meta-Analysis of SPAF NOAC Trials

Edoxaban vs VKA in Patients With AF and Valvular Heart Disease

Guideline Recommendations for Managing AF in Patients With Valvular Heart Disease

Bleeding in Patients With AF on Oral Anticoagulant and Antiplatelets Meta-Analysis of SPAF NOAC Trials

RE-DUAL PCI Primary Endpoint: Time to First Bleeding Event

Antithrombotic Therapy After ACS and PCI

Renal and Hepatic Impairment

Renal Function Meta-Analysis of All NOACs vs Warfarin

Renal Considerations for NOACs Clearance and Dosing

Hepatic Considerations for NOACs Clearance and Metabolism

Meta-Analysis of Risk for Drug-Induced Liver Injury With NOACs

Edoxaban vs Warfarin in Patients With AF and Hepatic Disease

Extremes in Weight

Relationship Between BMI and Outcomes Insights From the ENGAGE AF-TIMI 48 Trial

Use of NOACs in Extremes of Weight

Factors to Consider in Selecting the Appropriate NOAC

Abbreviations

Abbreviations (cont)

Abbreviations (cont)