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Can the Dual vs Triple Therapy Controversy in Patients With AF Undergoing PCI Be Put to Rest?

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Presentation on theme: "Can the Dual vs Triple Therapy Controversy in Patients With AF Undergoing PCI Be Put to Rest?"— Presentation transcript:

1 Can the Dual vs Triple Therapy Controversy in Patients With AF Undergoing PCI Be Put to Rest?

2

3 Patients with AF Undergoing PCI: Background

4 WOEST Study Design

5 WOEST - VKA in Patients With AF Undergoing PCI Any Bleeding

6 WOEST - VKA in Patients With AF Undergoing PCI Efficacy

7 PIONEER AF-PCI Study Design

8 PIONEER AF-PCI: Outcomes

9 PIONEER AF-PCI MACE (All Participants)

10 PIONEER AF-PCI Dosing Strategies

11 PIONEER AF-PCI Post-Hoc Analysis: All Cause Mortality and Recurrent Hospitalization

12 RE-DUAL PCI Study Design

13 RE-DUAL PCI Primary Endpoint - Bleeding

14 RE-DUAL PCI Individual Thromboembolic Endpoints

15 AUGUSTUS Study Design

16 AUGUSTUS: Primary Endpoint - Bleeding

17 AUGUSTUS: Secondary Endpoints

18 ENTRUST-AF PCI: Study Design

19 ENTRUST-AF PCI: Primary Endpoint - Bleeding

20 ENTRUST-AF PCI: Landmark Analysis for Primary Endpoint After Day 14

21 ENTRUST-AF PCI: Additional Bleeding Outcomes

22 ENTRUST-AF PCI: Main Efficacy Outcome (ITT Analysis)

23 Meta-Analysis of 4 NOAC trials in AF + PCI

24 Patients with AF Undergoing PCI: Meta-Analysis – NOACs vs VKA

25 ENTRUST-AF PCI: Main Efficacy Endpoint

26 Clinical Considerations…

27 What the Experts Say…

28 Asian Perspective

29 Recommendations for OAC and Antiplatelet Therapy in AF Undergoing PCI

30 2019 ESC Guidelines for Chronic Coronary Syndromes

31 Abbreviations

32 Abbreviations (cont)


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