Anti-inhibitor coagulant complex Drugbank ID : DB13151 Half life : 4-7 hours Description : Anti-inhibitor coagulant complex is a freeze-dried sterile human plasma fraction with factor VIII inhibitor bypassing activity to be reconstituted for intravenous administration. Anti-inhibitor coagulant complex contains mainly non-activated factors II, IX, and X and mainly activated factor VII. It is manufactured from large pools of human plasma.

Indication : Controlling bleeding episodes or bleeding during surgery in patients who have hemophilia A or B with inhibitors. Pharmacodynamics : Multiple interactions of the components in anti-inhibitor coagulant complex restore the impaired thrombin generation of hemophilia patients with inhibitors. In vitro, anti-inhibitor coagulant complex shortens the activated partial thromboplastin time of plasma containing factor VIII inhibitor.

Categories : Blood Coagulation Factors, Antihemophilic Agent Brands : Feiba Nf Company : E.R. Squibb & Sons, L.L.C. Form : Solid Route of administration : Intravenous

Dosage : 50-100 units/kg per dose (maximum: 100 units/kg [single dose], 200 units/kg/day [total daily dose]). Dosage and duration of treatment depend on the location and extent of bleeding and clinical condition of the patient. Contraindication : Known anaphylactic or severe hypersensitivity to anti-inhibitor coagulant complex or any component of the formulation, including factors of the kinin generating system; disseminated intravascular coagulation (DIC); acute thrombosis or embolism (including myocardial infarction) Side effects : chest pain or discomfort

Useful links http://www.feiba.com/us/forms/feiba_nf_pi.pdf , https://www.drugs.com/cdi/anti-inhibitor-coagulant-complex.html