Figure 1 Pathologic features of obesity-related glomerulopathy (ORG)

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Figure 1 Pathologic features of obesity-related glomerulopathy (ORG) Figure 1 | Pathologic features of obesity-related glomerulopathy (ORG). The glomeruli of patients with ORG a | are hypertrophied in comparison to b | glomeruli from non-obese age-matched control individuals (Jones methenamine silver stain, ×400). c | In patients with ORG, lesions of segmental sclerosis (arrow) tend to form at the vascular pole (perihilar) and segmentally obliterate the capillary lumina (Periodic acid–Schiff stain, ×400). d | Focal dilatation of the afferent arteriole and the glomerular perihilar capillaries provides morphologic evidence for a high single-nephron filtration rate (Periodic acid–Schiff stain, ×400). e | Some patients with ORG show a mild increase in mesangial matrix and thickening of glomerular basement membranes consistent with 'diabetoid' features (Jones methenamine silver stain, ×400). f | Glomerulus from a patient with advanced ORG showing a large segmental lesion of sclerosis (arrow) involving nearly half the tuft with prominent tubular atrophy, interstitial fibrosis and chronic inflammation (Masson trichrome stain, ×200). g | Electron micrograph (×6,000) showing very mild (approximately 15%) foot process effacement in a patient with ORG who had urine protein of 2.8 g per day. The podocyte cell body appears hypertrophied. h | The mesangial cells contain focal intracytoplasmic lipid vacuoles (arrows). A mild increase in mesangial matrix and moderate foot process effacement are also visible (electron micrograph, ×4000). D’Agati, V. D. et al. (2016) Obesity-related glomerulopathy: clinical and pathologic characteristics and pathogenesis Nat. Rev. Nephrol. doi:10.1038/nrneph.2016.75