1. Four major patterns of glomerular injury in podocytopathies.
Four major patterns of glomerular injury in podocytopathies. MCN: No changes are present on light microscopy. FSGS: FSGS is characterized by segmental solidification of the tuft with accumulation of extracellular matrix. Synechiae form between the tuft and Bowman's capsule. Podocytes are lost in the areas of sclerosis. DMS: Mesangial expansion as a result of accumulated extracellular matrix is the characteristic feature and is accompanied by hypertrophy and mild cobblestone hyperplasia of overlying podocytes. CG: The characteristic features of CG include wrinkling and folding of the glomerular basement membranes (collapse) and proliferation of overlying podocytes forming pseudocrescents. Numerous protein reabsorption droplets are present in the podocyte cytoplasm. Magnifications: ×40 in MCN and FSGS; ×60 in DMS and CG (Silver stain for all).
Laura Barisoni et al. CJASN 2007;2:
©2007 by American Society of Nephrology