Epigenetics, infertility, and cancer: future directions

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Presentation transcript:

Epigenetics, infertility, and cancer: future directions Emma James, B.S., Timothy G. Jenkins, Ph.D. Fertility and Sterility Volume 109, Issue 1, Pages 27-32 (January 2018) DOI: 10.1016/j.fertnstert.2017.11.006 Copyright © 2017 Terms and Conditions

Figure 1 Some of the most common epigenetic marks that are associated with gene activation or repression. DNA methylation at promoters at cytosine-phosphate-guanine (CpG) dinucleotides can regulate the activation or silencing of gene transcription. Similarly, histone modifications including ubiquitination (ub), monomethylation (me), dimethylation (me2), trimethylation (me3), and acetylation (ac) at various histones (H3, H2A, H4, H2B, etc.) can drive gene regulation. These histone modifications typically occur at histone tails on lysine residues (K4, K9, K27, etc.). Fertility and Sterility 2018 109, 27-32DOI: (10.1016/j.fertnstert.2017.11.006) Copyright © 2017 Terms and Conditions