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Asif Rashid, Jean Pierre J. Issa  Gastroenterology 

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1 CpG island methylation in gastroenterologic neoplasia: A maturing field 
Asif Rashid, Jean Pierre J. Issa  Gastroenterology  Volume 127, Issue 5, Pages (November 2004) DOI: /j.gastro Copyright © 2004 American Gastroenterological Association Terms and Conditions

2 Figure 1 Model of the DNA methylation-associated gene silencing loop in cancer. The cascade of events may start with DNA methylation triggering histone modifications or with histone H3 lysine-9 (K9) methylation triggering silencing, which then promotes DNA methylation. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2004 American Gastroenterological Association Terms and Conditions


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