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NF-κB: A Coordinator for Epigenetic Regulation by MLL

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1 NF-κB: A Coordinator for Epigenetic Regulation by MLL
Susumu Goyama, James C. Mulloy  Cancer Cell  Volume 24, Issue 4, Pages (October 2013) DOI: /j.ccr Copyright © 2013 Elsevier Inc. Terms and Conditions

2 Figure 1 Therapeutic Targeting of Canonical NF-κB Pathway in MLL-Fusion Leukemia Inhibition of IKK/NF-κB signaling results in loss of epigenetic marks on HOXA9 and MEIS1 promoters, which ultimately induces cell-cycle arrest, apoptosis, and differentiation in MLL fusion leukemia cells. me3, trimethylation; me2, dimethylation. The figure is modeled on the online graphical abstract in Kuo et al. (2013), with some modifications. Cancer Cell  , DOI: ( /j.ccr ) Copyright © 2013 Elsevier Inc. Terms and Conditions


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