Genome sequencing informatics

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Presentation transcript:

Genome sequencing informatics Gabor T. Marth Department of Biology Boston College Chestnut Hill, MA 02467

Genome sequence the complete genome sequence contains (almost) all information carried by the chromosomes the primary template on which to outline functional features of our genetic code (genes, regulatory elements, secondary structure, tertiary structure, etc.)

Completed genomes ~3,000 Mb >100 Mb ~100 Mb ~1 Mb

Sequencing strategies Whole-genome shotgun sequencing Clone-based shotgun sequencing

Sequencing software tools PHRED PHRAP CONSED, AUTOFINISH