What Predicts Disability Progression in Multiple Sclerosis?

Overview: Prognostic Factors in MS

Clinical Prognostic Factors

Early Clinical Events Predict Disability Progression

MRI Prognostic Factors

Gray Matter Atrophy and Loss of Functional Connectivity

Multimodal EPs Predict Risk for Disability

OCT Alterations Predict Development of Disability

Neuronal Damage and Long-Term Synaptic Potentiation

LTP Compensation for Neuronal Damage

Predicting Response to Treatment

BENEFIT Study: Extent of Disease Activity Predicts Treatment Response

BENEFIT Study: Baseline Vitamin D Predicts Time to CDMS

MSCRG Study: Early Predictors of Long-Term Outcomes

MAGNIMS Network: Early Predictors of Short-Term Outcomes

Treating to Target NEDA

NEDA as a Predictor of Brain Atrophy and Optic Nerve Degeneration

CLIMB Cohort Study: Evolution of NEDA Over the Disease Course

NEDA as a Predictor of Long-Term Outcomes

Conclusions

Abbreviations

Abbreviations (cont)