1. Inhaled Antibiotics for Patients With CF in the Era of CFTR Modulators

3. Program Overview

4. Treatment Goals in CF

5. Prevalence of Pulmonary Infection in Children and Adolescents With CF

6. Prevalence of Pulmonary Infection in Adults With CF

7. Emerging Infections in CF

8. CFTR Dysfunction, Chronic Infection, and Disease Progression

9. Targeting the Airway Microenvironment With Inhaled Antibiotics

10. Managing Chronic P aeruginosa Infection

11. Considerations in Managing Chronic P aeruginosa Infection in Children

12. Pulmonary Exacerbations

13. Delivery of Inhaled Antibiotics

14. Challenges of Eradicating P aeruginosa in Children

15. Inhaled Antibiotics Targeting P aeruginosa

16. Inhaled Antibiotic Therapy: Guideline Recommendations

17. Continuous Alternating Therapy: Rationale

18. CAT Study: Design

19. CAT Study: Results

20. Using CAT in Clinical Practice

21. Maximizing Delivery of Inhaled Antibiotics

22. Predictors of Adherence to Inhaled Antibiotics

23. Rates of Adherence to CF Therapies

24. Effects of Therapy Adherence on Exacerbations

25. Using Inhaled Antibiotics Alongside CFTR Modulators

26. Potential Impact of CFTR Modulators on the Microbiome

27. Conclusions

28. Abbreviations

29. Abbreviations (cont)