Volume 119, Issue 4, Pages (October 2000)

Slides:

Advertisements

Similar presentations

Cdx2 ectopic expression induces gastric intestinal metaplasia in transgenic mice Debra G. Silberg, Jessica Sullivan, Eugene Kang, Gary P. Swain, Jennifer.

Advertisements

Tylosis esophageal cancer locus on chromosome 17q25

Mouse Models of Colon Cancer

Diffuse Type Gastric and Lobular Breast Carcinoma in a Familial Gastric Cancer Patient with an E-Cadherin Germline Mutation Gisela Keller, Holger Vogelsang,

Volume 118, Issue 6, Pages (June 2000)

Volume 114, Issue 3, Pages (March 1998)

Janusz A. Jankowski, Nick A. Wright, Stephen J

(A) Region of esophagus demonstrating Barrett esophagus: The normal squamous epithelium (left margin of figure) is replaced by specialized columnar epithelium.

Thomas Kirchner, Thomas Brabletz The American Journal of Pathology

Volume 115, Issue 2, Pages (August 1998)

Volume 115, Issue 3, Pages (September 1998)

Preinvasive Neoplasia in the Stomach: Diagnosis and Treatment

Volume 123, Issue 2, Pages (August 2002)

Volume 137, Issue 1, Pages (July 2009)

Mouse Models of Colon Cancer

Volume 122, Issue 3, Pages (March 2002)

Carcinogenesis of Helicobacter pylori

First successful treatment of a primary high-grade gastric MALT lymphoma by eradication therapy for Helicobacter pylori Stephan Timm, Marco Sailer, Karl–hermann.

MAPing the Role of Kras Mutations in Hyperplastic Polyps

Volume 119, Issue 4, Pages (October 2000)

Volume 122, Issue 1, Pages (January 2002)

Volume 123, Issue 5, Pages (November 2002)

Volume 6, Issue 2, Pages (February 2010)

Expanding the Lauren Classification: A New Gastric Cancer Subtype?

Volume 134, Issue 2, Pages (February 2008)

Volume 126, Issue 2, Pages (February 2004)

Volume 118, Issue 6, Pages (June 2000)

Volume 122, Issue 2, Pages (February 2002)

Volume 115, Issue 4, Pages (October 1998)

Volume 142, Issue 3, Pages (March 2012)

Volume 136, Issue 4, Pages (April 2009)

Volume 128, Issue 5, Pages (May 2005)

Volume 122, Issue 7, Pages (June 2002)

Volume 121, Issue 5, Pages (November 2001)

Incidence of gastric cancer and breast cancer in CDH1 (E-cadherin) mutation carriers from hereditary diffuse gastric cancer families Paul D.P. Pharoah,

Volume 131, Issue 4, Pages (October 2006)

Volume 128, Issue 4, Pages (April 2005)

Volume 122, Issue 3, Pages (March 2002)

Volume 115, Issue 1, Pages (July 1998)

Volume 141, Issue 6, Pages e2 (December 2011)

Volume 123, Issue 1, Pages (July 2002)

Volume 122, Issue 1, Pages (January 2002)

Molecular Aspects of Melanocytic Dysplastic Nevi

Volume 115, Issue 5, Pages (November 1998)

Volume 119, Issue 3, Pages (September 2000)

Volume 132, Issue 2, Pages (February 2007)

Challenges and Pitfalls in HNPCC Screening by Microsatellite Analysis and Immunohistochemistry Annegret Müller, Giuseppe Giuffre, Tina Bocker Edmonston,

Volume 122, Issue 3, Pages (March 2002)

The role of transforming growth factor beta-2, beta-3 in mediating apoptosis in the murine intestinal mucosa Nicole Dünker, Kai Schmitt, Norbert Schuster,

The diagnosis of Barrett's esophagus: goblets, goblets, goblets

Volume 117, Issue 1, Pages (July 1999)

Tylosis esophageal cancer locus on chromosome 17q25

Volume 114, Issue 6, Pages (June 1998)

Volume 22, Issue 3, Pages (September 2012)

Volume 122, Issue 4, Pages (April 2002)

Postnatal Lethality of P-Cadherin/Desmoglein 3 Double Knockout Mice: Demonstration of a Cooperative Effect of these Cell Adhesion Molecules in Tissue.

Aiden C.J. Marshall, Frank Alderuccio, Ban-Hock Toh Gastroenterology

Volume 123, Issue 6, Pages (December 2002)

Volume 114, Issue 4, Pages (April 1998)

Volume 123, Issue 4, Pages (October 2002)

Volume 120, Issue 7, Pages (June 2001)

Zheng Liu, MD, Jean Kim, MD, PhD, Joseph P

Janusz A. Jankowski, Dawn Provenzale, Paul Moayyedi Gastroenterology

Role of the amino-terminal domain of simian virus 40 early region in inducing tumors in secretin-expressing cells in transgenic mice Christelle Ratineau,

F. Henry Ellis, MD, PhD, Xiangjun Xu, MD, PhD, Matthew H

Volume 123, Issue 1, Pages (July 2002)

Volume 119, Issue 4, Pages (October 2000)

Volume 92, Issue 5, Pages (March 1998)

Isolated Antral Narrowing Associated With Gastrointestinal Cryptosporidiosis in Acquired Immunodeficiency Syndrome EUGENIO CERSOSIMO, M.D., Ph.D. Mayo.

Gross and histologic features of the intestinal neoplasms initiated by the Apc1638N mutation. Gross and histologic features of the intestinal neoplasms.

Presentation transcript:

Volume 119, Issue 4, Pages 1045-1053 (October 2000) E-cadherin and adenomatous polyposis coli mutations are synergistic in intestinal tumor initiation in mice Ron Smits, Patricia Ruiz, Salvador Diaz–Cano, Arne Luz, Shantie Jagmohan–Changur, Cor Breukel, Carmen Birchmeier, Walter Birchmeier, Riccardo Fodde Gastroenterology Volume 119, Issue 4, Pages 1045-1053 (October 2000) DOI: 10.1053/gast.2000.18162 Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 1 Histogram showing the size distribution of intestinal tumors in Apc+/1638N and Apc+/1638N/E-cad+/− animals. Gastroenterology 2000 119, 1045-1053DOI: (10.1053/gast.2000.18162) Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 2 Example of a gastric lesion observed in an Apc+/1638N/E-cad+/− animal. (A) Normal gastric epithelium from the pyloric region of the stomach. (B) The upper part shows an invasive intestinal-type adenocarcinoma. Gastric mucosa epithelium shows interspersed goblet cells as sign of intestinal metaplasia (arrowhead) and regenerative gastric epithelium. (C) A detail of an invasive adenocarcinoma revealing pleomorphic cells with prominent nucleoli and tubular formation (arrowhead). The irregular glands in the center represent early invasion of the stroma (arrow). Gastroenterology 2000 119, 1045-1053DOI: (10.1053/gast.2000.18162) Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 3 Example of tumor LOH analysis at the Apc and E-cadherin locus. C1–C2, DNA isolated from normal intestinal mucosa; T1–T5, DNA isolated from tumor samples. All tumors show a clear loss of the wild-type Apc allele, but all have retained the wild-type E-cadherin allele. Gastroenterology 2000 119, 1045-1053DOI: (10.1053/gast.2000.18162) Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 4 Immunohistochemical staining of E-cadherin in intestinal tumors derived from (A) Apc+/1638N or (C) Apc+/1638N/E-cad+/− animals. (B and D) Sections derived from the same tumors were also stained for β-catenin. (E) E-cadherin staining of an intestinal tumor derived from an Apc+/1638N/E-cad+/− animal covered by a layer of normal intestinal epithelium. Membranous staining for E-cadherin remains in tumor cells, although the expression level is clearly reduced compared with the normal intestinal epithelium. Gastroenterology 2000 119, 1045-1053DOI: (10.1053/gast.2000.18162) Copyright © 2000 American Gastroenterological Association Terms and Conditions