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Gross and histologic features of the intestinal neoplasms initiated by the Apc1638N mutation. Gross and histologic features of the intestinal neoplasms.

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Presentation on theme: "Gross and histologic features of the intestinal neoplasms initiated by the Apc1638N mutation. Gross and histologic features of the intestinal neoplasms."— Presentation transcript:

1 Gross and histologic features of the intestinal neoplasms initiated by the Apc1638N mutation.
Gross and histologic features of the intestinal neoplasms initiated by the Apc1638N mutation. Gross appearance of representative intestinal adenomas (A) and adenocarcinoma (D) observed in Apc1638N/wt;Tgfbr2E2flx/E2flx and Apc1638N/wt;Tgfbr2IEKO mice, respectively. Photomicrographs of H&E–stained sections of a representative adenoma [magnifications, ×40 (B) and ×100 (C)] and an adenocarcinoma [magnifications, ×40 (E) and ×100 (F)]. Cystic structures filled with mucin (arrow) were frequently observed in the invasive neoplasms, as well as a dramatic desmoplastic response (*) in the invasive component of such tumors (F). Nina M. Muñoz et al. Cancer Res 2006;66: ©2006 by American Association for Cancer Research

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