Presentation is loading. Please wait.

Presentation is loading. Please wait.

Molecular Aspects of Melanocytic Dysplastic Nevi

Published byJonathan Moore Modified over 5 years ago

Similar presentations

Presentation on theme: "Molecular Aspects of Melanocytic Dysplastic Nevi"— Presentation transcript:

1 Molecular Aspects of Melanocytic Dysplastic Nevi
Mahmoud Rezk Abd-Elwahed Hussein, Gary Stewart Wood  The Journal of Molecular Diagnostics  Volume 4, Issue 2, Pages (May 2002) DOI: /S (10) Copyright © 2002 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

2 Figure 1 Histological appearance of melanocytic dysplastic nevus (A) and cutaneous malignant melanoma (B). The Journal of Molecular Diagnostics 2002 4, 71-80DOI: ( /S (10) ) Copyright © 2002 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

3 Figure 2 The reported frequency of microsatellite instability (MSI) and loss of heterozygosity (LOH) on several chromosomal arms in melanocytic dysplastic nevi. The bars compare the frequency of these genetic changes among the different studies The Journal of Molecular Diagnostics 2002 4, 71-80DOI: ( /S (10) ) Copyright © 2002 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

4 Figure 3 Genetic changes in melanocytic dysplastic nevi. Left:Microsatellite instability (MSI), with the arrowhead indicating the appearance of a novel band in the tumor (T) DNA as compared to DNA from the normal tissues (N). Right:Loss of heterozygosity (LOH) in the tumor DNA, with the arrowhead indicating loss of upper allele in the tumor. The Journal of Molecular Diagnostics 2002 4, 71-80DOI: ( /S (10) ) Copyright © 2002 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

5 Figure 4 Immunohistochemical staining of MMR proteins in melanocytic dysplastic nevi (MDN). A:hMLH1 expression in the normal epidermis. Note the nuclear expression pattern (arrow):B: hMSH2 expression in MDN. Positively (arrow) and negatively (arrowhead) stained cells are observed in both MDN and CMM. The Journal of Molecular Diagnostics 2002 4, 71-80DOI: ( /S (10) ) Copyright © 2002 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

Download ppt "Molecular Aspects of Melanocytic Dysplastic Nevi"

Similar presentations

Functional Analysis of the Neurofibromatosis Type 2 Protein by Means of Disease- Causing Point Mutations Renee P. Stokowski, David R. Cox The American.

Functional Analysis of the Neurofibromatosis Type 2 Protein by Means of Disease- Causing Point Mutations Renee P. Stokowski, David R. Cox The American.
Measurement of Relative Copy Number of CDKN2A/ARF and CDKN2B in Bladder Cancer by Real-Time Quantitative PCR and Multiplex Ligation-Dependent Probe Amplification.

Measurement of Relative Copy Number of CDKN2A/ARF and CDKN2B in Bladder Cancer by Real-Time Quantitative PCR and Multiplex Ligation-Dependent Probe Amplification.
Development of a Novel One-Tube Isothermal Reverse Transcription Thermophilic Helicase-Dependent Amplification Platform for Rapid RNA Detection James Goldmeyer,

Development of a Novel One-Tube Isothermal Reverse Transcription Thermophilic Helicase-Dependent Amplification Platform for Rapid RNA Detection James Goldmeyer,
CyclinD1/CyclinD3 Ratio by Real-Time PCR Improves Specificity for the Diagnosis of Mantle Cell Lymphoma Carol D. Jones, Katherine H. Darnell, Roger A.

CyclinD1/CyclinD3 Ratio by Real-Time PCR Improves Specificity for the Diagnosis of Mantle Cell Lymphoma Carol D. Jones, Katherine H. Darnell, Roger A.
Design and Multiseries Validation of a Web-Based Gene Expression Assay for Predicting Breast Cancer Recurrence and Patient Survival Ryan K. Van Laar The.

Design and Multiseries Validation of a Web-Based Gene Expression Assay for Predicting Breast Cancer Recurrence and Patient Survival Ryan K. Van Laar The.
Reduced Level of CD44 and Hyaluronan Associated with Unfavorable Prognosis in Clinical Stage I Cutaneous Melanoma  Jari M. Karjalainen, Raija H. Tammi,

Reduced Level of CD44 and Hyaluronan Associated with Unfavorable Prognosis in Clinical Stage I Cutaneous Melanoma  Jari M. Karjalainen, Raija H. Tammi,
A Genome-Wide High-Resolution Array-CGH Analysis of Cutaneous Melanoma and Comparison of Array-CGH to FISH in Diagnostic Evaluation  Lu Wang, Mamta Rao,

A Genome-Wide High-Resolution Array-CGH Analysis of Cutaneous Melanoma and Comparison of Array-CGH to FISH in Diagnostic Evaluation  Lu Wang, Mamta Rao,
Jack Lawler, Wei-Min Miao, Mark Duquette, Noël Bouck, Roderick T

Jack Lawler, Wei-Min Miao, Mark Duquette, Noël Bouck, Roderick T
Volume 50, Issue 5, Pages (November 2006)

Volume 50, Issue 5, Pages (November 2006)
Tumor Microsatellite Instability in Early Onset Gastric Cancer

Tumor Microsatellite Instability in Early Onset Gastric Cancer
Statistical Considerations for Immunohistochemistry Panel Development after Gene Expression Profiling of Human Cancers  Rebecca A. Betensky, Catherine.

Statistical Considerations for Immunohistochemistry Panel Development after Gene Expression Profiling of Human Cancers  Rebecca A. Betensky, Catherine.
Novel Functional Single Nucleotide Polymorphisms in the Latent Transforming Growth Factor-β Binding Protein-1L Promoter  Tomomi Higashi, Satoru Kyo, Masaki.

Novel Functional Single Nucleotide Polymorphisms in the Latent Transforming Growth Factor-β Binding Protein-1L Promoter  Tomomi Higashi, Satoru Kyo, Masaki.
Targeted Next-Generation Sequencing for Hereditary Cancer Syndromes

Targeted Next-Generation Sequencing for Hereditary Cancer Syndromes
Volume 50, Issue 5, Pages (November 2006)

Volume 50, Issue 5, Pages (November 2006)
Molecular Diagnosis of Clear Cell Sarcoma

Molecular Diagnosis of Clear Cell Sarcoma
Hybrid Model Integrating Immunohistochemistry and Expression Profiling for the Classification of Carcinomas of Unknown Primary Site  Barbara A. Centeno,

Hybrid Model Integrating Immunohistochemistry and Expression Profiling for the Classification of Carcinomas of Unknown Primary Site  Barbara A. Centeno,
Hendrikus J. Dubbink, Peggy N. Atmodimedjo, Ronald van Marion, Niels M

Hendrikus J. Dubbink, Peggy N. Atmodimedjo, Ronald van Marion, Niels M
Molecular Genetics of Pediatric Soft Tissue Tumors

Molecular Genetics of Pediatric Soft Tissue Tumors
Distinguishing de Novo Second Cancer Formation from Tumor Recurrence

Distinguishing de Novo Second Cancer Formation from Tumor Recurrence
KRAS, NRAS, PIK3CA Exon 20, and BRAF Genotypes in Synchronous and Metachronous Primary Colorectal Cancers  Katharina Balschun, Jochen Haag, Ann-Kathrin.

KRAS, NRAS, PIK3CA Exon 20, and BRAF Genotypes in Synchronous and Metachronous Primary Colorectal Cancers  Katharina Balschun, Jochen Haag, Ann-Kathrin.

Similar presentations

Ads by Google