Figure 4 Host damage from infection-related inflammatory

Slides:

Advertisements

Similar presentations

Immune Reconstitution Inflammatory Syndrome (IRIS)

Advertisements

Cryptococcal IRIS: Pathogenesis & Pearls for Clinical Management

≥18 years HIV+, cART-naïve First CM Intensive Ampho 14 d Consolidation 400mg Fluconazole 12 weeks Maintenance 200mg Fluconazole therapy W02 W04 W08 W12.

Table 3 Limb-girdle muscular dystrophy standardized data collection form and HPO mapping Thompson, R. & Straub, V. et al. (2016) Limb-girdle muscular dystrophies.

ART was initiated when indicated by WHO and national guidelines

Nat. Rev. Neurol. doi: /nrneurol

Table 2. Cerebrospinal Fluid Analysis (CSF analysis)

Dr Dawood Quiz questions.

Figure 3 Life expectancy at birth in all countries included

Figure 4 Paradoxical immune reconstitution inflammatory syndrome

Figure 4 Time course of the development of physiological changes

Figure 1 Concept of the therapeutic index

Nat. Rev. Neurol. doi: /nrneurol

Figure 2 Systemic immune responses to cryptococcal antigen

Cryptococcosis: Treatment outcome

Figure 2 Three-step approach to the assessment and management

Nat. Rev. Neurol. doi: /nrneurol

Figure 3 Proportion of patients for whom NEDA

Figure 5 Number of AHSCT procedures for

Figure 3 Nucleic acid sensors in SLE

Nat. Rev. Neurol. doi: /nrneurol

Figure 1 CAR-T-cell design

Figure 5 Corticosteroid treatment can reduce brain

Figure 2 Co-stimulatory receptors as immunomodulatory targets

Figure 4 Combination immunotherapeutic approaches with imatinib

Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Neurol. doi: /nrneurol

Paradoxical immune reconstitution inflammatory syndrome associated with cryptococcal meningitis in China: a 5-year retrospective cohort study S. Yan,

Cryptococcal Immune Reconstitution Inflammatory Syndrome

Figure 1 Associations between baseline cerebrospinal fluid

Figure 2 Proposed model of therapeutic mechanisms of AHSCT

Figure 2 Pathological features of opportunistic infections of the CNS

Nat. Rev. Neurol. doi: /nrneurol

Figure 3 Hypothetical mechanisms of smoking-associated

Nat. Rev. Neurol. doi: /nrneurol

Fishing Out a Sensor for Anti-inflammatory Oils

Cryptococcosis: Epidemiology of cryptococcal disease

Figure 4 Flow chart of the MDS MSA Study Group aims

Figure 3 Genetic pleiotropy in ALS

Nat. Rev. Neurol. doi: /nrneurol

Figure 1 Evolution of multiple sclerosis

Figure 1 Zika virus transmission and clinical syndromes

Nat. Rev. Rheumatol. doi: /nrrheum

Immunodeficiency (2 of 2)

Figure 3 Stroke-related deaths and DALYs by country development status

Figure 3 MRI findings in opportunistic infections of the CNS

Cryptococcal Immune Reconstitution Inflammatory Syndrome

L. Y. A. Chai, R. Naesens, A. L. Khoo, M. V. Abeele, K

Nat. Rev. Neurol. doi: /nrneurol

Figure 2 Logistical requirements for autologous

Figure 3 Potential interplay between physiological

Figure 2 Cellular pathways implicated in CIPN

Cryptococcosis: Epidemiology of cryptococcal disease

Cryptococcosis: Treatment outcome

Figure 1 Timing of the effects of deep brain stimulation

Nat. Rev. Clin. Oncol. doi: /nrclinonc

Fishing Out a Sensor for Anti-inflammatory Oils

Figure 3 Rett syndrome severity and age at diagnosis by mutation type

Nat. Rev. Neurol. doi: /nrneurol

Time course of inflammation, tissue damage and resolution of pneumonia: potential adjuvant therapies. Time course of inflammation, tissue damage and resolution.

Immune reconstitution inflammatory syndrome (IRIS) associated with Mycobacterium tuberculosis (TB) infection. a) In healthy individuals in response to.

Figure 2 Histopathological features in CIDP

Figure 1 The role of macrophages in RA

Figure 1 MRIs (case 1)‏ MRIs (case 1) An enlarging T2 lesion in the cerebral white matter near the angular gyrus and a new lesion in the left middle cerebellar.

Figure 2 MRIs (cases 2 and 3)‏

Table 1. Diagnostic methods for systemic fungal infection (n=70)

Mesenchymal Stromal Cells: New Directions

Damage-associated molecular pattern (DAMP)-induced activation of Toll-like receptors (TLRs). Damage-associated molecular pattern (DAMP)-induced activation.

Replication and intercellular transmission of HIV-1 is increased during antigen presentation. Replication and intercellular transmission of HIV-1 is increased.

Cytokines and cytokine receptors involved in type I immunity in tuberculosis. Cytokines and cytokine receptors involved in type I immunity in tuberculosis.

Presentation transcript:

Figure 4 Host damage from infection-related inflammatory syndromes in HIV-positive and in HIV-negative cryptococcal meningitis Figure 4 | Host damage from infection-related inflammatory syndromes in HIV-positive and in HIV-negative cryptococcal meningitis. Some HIV-positive cryptococcal meningitis (CM) patients who initially improve with antifungal therapy later re-present with CM-associated immune reconstitution inflammatory syndrome after initiation of effective antiretroviral therapy. Such patients present with clinical deterioration although CSF cultures do not show active infection, and an aggravated T-cell and proinflammatory macrophage response. HIV-negative, previously healthy patients with CM may deteriorate clinically despite effective antifungal therapy and negative CSF cultures, with a similar post-infectious immune response syndrome consisting of a similar T-cell response but a defective M2 macrophage polarization that is ineffective in clearing fungal antigen. Man, mannose; TLR2, Toll-like receptor 2. Williamson, P. R. et al. (2016) Cryptococcal meningitis: epidemiology, immunology, diagnosis and therapy Nat. Rev. Neurol. doi:10.1038/nrneurol.2016.167