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Figure 1 CAR-T-cell design

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Presentation on theme: "Figure 1 CAR-T-cell design"— Presentation transcript:

1 Figure 1 CAR-T-cell design
Figure 1 | CAR-T-cell design. All chimeric antigen receptor (CAR) designs contain an antigen-recognition domain and a signalling domain that provides 'signal 1' to activate T cells. Only this signalling domain is present in first-generation CARs. By contrast, a co-stimulatory signalling domain that provides 'signal 2' is added in second-generation CARs, and in third-generation CARs two co-stimulatory signalling domains are added. Jackson, H. J. et al. (2016) Driving CAR T‑cells forward Nat. Rev. Clin. Oncol. doi: /nrclinonc

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