A New Twist on Radiation Oncology: Low-Dose Irradiation Elicits Immunostimulatory Macrophages that Unlock Barriers to Tumor Immunotherapy Michele De Palma,

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A New Twist on Radiation Oncology: Low-Dose Irradiation Elicits Immunostimulatory Macrophages that Unlock Barriers to Tumor Immunotherapy Michele De Palma, George Coukos, Douglas Hanahan Cancer Cell Volume 24, Issue 5, Pages 559-561 (November 2013) DOI: 10.1016/j.ccr.2013.10.019 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 Low Dose Irradiation Programs/Reprograms Macrophages to Promote Antitumor Immunity Irradiation of macrophages and/or myeloid progenitors in tumor-bearing mice, or ex vivo followed by adoptive transfer, elicits infiltration of tumors by iNOS-expressing macrophages, which normalize the tumor vasculature and increase the influx of CD8 T cells (either endogenous or following adoptive transfer). The net result is tumor shrinkage and remarkable survival benefit in a mouse model of multifocal pancreatic neuroendocrine cancer (PanNET), illustrating successful immunotherapy of late stage solid tumors involving a clinically feasible and likely combinable intervention. Cancer Cell 2013 24, 559-561DOI: (10.1016/j.ccr.2013.10.019) Copyright © 2013 Elsevier Inc. Terms and Conditions