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Tipping the Balancing ACT

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Presentation on theme: "Tipping the Balancing ACT"— Presentation transcript:

1 Tipping the Balancing ACT
Shari Pilon-Thomas, Brian Ruffell  Cancer Cell  Volume 30, Issue 3, Pages (September 2016) DOI: /j.ccell Copyright © 2016 Elsevier Inc. Terms and Conditions

2 Figure 1 Tip-DCs Are Necessary for Adoptive T Cell Therapy
CD40L on exogenously administered anti-tumor CD8+ T cells combines with CD40L expression by endogenous CD8+ T cells to drive expression of NOS2 by monocyte-derived Tip-DCs within tumors. Production of NO− by Tip-DCs may indirectly support a T cell response or may be directly cytotoxic toward tumor cells, leading to improved survival of tumor-bearing mice treated with ACT. Cancer Cell  , DOI: ( /j.ccell ) Copyright © 2016 Elsevier Inc. Terms and Conditions

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