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Tumor Evolution: A Problem of Histocompatibility

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Presentation on theme: "Tumor Evolution: A Problem of Histocompatibility"— Presentation transcript:

1 Tumor Evolution: A Problem of Histocompatibility
Natalie I. Vokes, Eliezer M. Van Allen  Cell  Volume 171, Issue 6, Pages (November 2017) DOI: /j.cell Copyright © 2017 Elsevier Inc. Terms and Conditions

2 Figure 1 The Role of HLA-Mediated Antigen Presentation in Immune Detection and Elimination of Cancer (A) Mutated cancer proteins are presented as neoantigens via the HLA-containing MHC class I complex to CD8+ T cells, triggering destruction of the transformed cell in a process called immunoediting. (B and C) Mechanisms of loss-of-antigen presentation, leading to cancer cell survival either by incompatible binding between the transformed protein and the individual’s HLA (B) or by loss of HLA heterozygosity (C). Cell  , DOI: ( /j.cell ) Copyright © 2017 Elsevier Inc. Terms and Conditions

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