The Kinase-Independent, Second Life of CDK6 in Transcription

Slides:

Advertisements

Similar presentations

Aurora Kinases and Protein Phosphatase 1 Mediate Chromosome Congression through Regulation of CENP-E Yumi Kim, Andrew J. Holland, Weijie Lan, Don W. Cleveland.

Advertisements

Gain of function of mutant p53: The mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation Silvia Di Agostino,

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell

Origins of Metastatic Traits Sakari Vanharanta, Joan Massagué Cancer Cell Volume 24, Issue 4, Pages (October 2013) DOI: /j.ccr

Making Proteins in the Powerhouse B. Martin Hällberg, Nils-Göran Larsson Cell Metabolism Volume 20, Issue 2, Pages (August 2014) DOI: /j.cmet

Tumor-Derived Jagged1 Promotes Osteolytic Bone Metastasis of Breast Cancer by Engaging Notch Signaling in Bone Cells Nilay Sethi, Xudong Dai, Christopher.

The Transcription Factor Foxo1 Controls Central-Memory CD8+ T Cell Responses to Infection Myoungjoo V. Kim, Weiming Ouyang, Will Liao, Michael Q. Zhang,

Extracellular Matrix Protein Anosmin Promotes Neural Crest Formation and Regulates FGF, BMP, and WNT Activities Yukinori Endo, Hiroko Ishiwata-Endo, Kenneth.

Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages (March 2014) DOI: /j.stem

ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics Carlos L. Arteaga, Jeffrey A. Engelman Cancer Cell Volume.

Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia Tim C.P. Somervaille, Michael L. Cleary Cancer Cell.

Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53- independent and mTORC1-dependent manner Jennifer E. Skeen, Prashanth.

CDK Inhibitors: Cell Cycle Regulators and Beyond Arnaud Besson, Steven F. Dowdy, James M. Roberts Developmental Cell Volume 14, Issue 2, Pages

Modeling Inducible Human Tissue Neoplasia Identifies an Extracellular Matrix Interaction Network Involved in Cancer Progression Jason A. Reuter, Susana.

Shaping Genetic Alterations in Human Cancer: The p53 Mutation Paradigm Thierry Soussi, Klas G. Wiman Cancer Cell Volume 12, Issue 4, Pages (October.

A Conditional Mouse Model of Synovial Sarcoma: Insights into a Myogenic Origin Malay Haldar, Jeffrey D. Hancock, Cheryl M. Coffin, Stephen L. Lessnick,

Inflammation and Cancer: IL-6 and STAT3 Complete the Link

Charles Swanton, Julian Downward Cancer Cell

We Contain Multitudes: The Protean Face of Retinoblastoma

NF-κB: A Coordinator for Epigenetic Regulation by MLL

Linking miRNA Regulation to BCR-ABL Expression: The Next Dimension

Tissue Culture as a Hostile Environment: Identifying Conditions for Breast Cancer Progression Studies Jerry W. Shay, Woodring E. Wright Cancer Cell

Warren S. Pear, M. Celeste Simon Cancer Cell

PI3K Regulatory Subunits Lose Control in Cancer

HSF1 in Translation Cancer Cell

Mutant p53 gain of function: The NF-Y connection

A Time to Divide: Does the Circadian Clock Control Cell Cycle?

Volume 14, Issue 2, Pages (August 2008)

Multiple Effects of Angiopoietin-2 Blockade on Tumors

A Sweet New Role for EGFR in Cancer

Oh what a tangled web it weaves: BRCA1 and DNA decatenation

Agonizing Integrin Antagonists?

Annapoorni Rangarajan, Sue J. Hong, Annie Gifford, Robert A. Weinberg

MDS Is a Stem Cell Disorder After All

Volume 26, Issue 1, Pages 1-2 (July 2014)

T.S. Karin Eisinger-Mathason, M. Celeste Simon Cancer Cell

Suppressing NFAT Increases VEGF Signaling in Hemangiomas

Eun-Jung Jung, George A. Calin Cancer Cell

Stressed-Out HSCs Turn Up p38α and Purine to Proliferate

Volume 13, Issue 1, Pages 1-2 (January 2008)

A Radical Role for p38 MAPK in Tumor Initiation

Tissue Culture as a Hostile Environment: Identifying Conditions for Breast Cancer Progression Studies Jerry W. Shay, Woodring E. Wright Cancer Cell

In This Issue Cell Volume 158, Issue 5, (August 2014)

PICS-ure This: Prosenescence Therapy?

Coordinate Transcriptional Regulation by ERG and Androgen Receptor in Fusion- Positive Prostate Cancers Yu Chen, Charles L. Sawyers Cancer Cell Volume.

Volume 6, Issue 3, Pages (September 2004)

The great MYC escape in tumorigenesis

Frances Balkwill, Kellie A. Charles, Alberto Mantovani Cancer Cell

Bryan Krock, Nicolas Skuli, M. Celeste Simon Cell Metabolism

Multiple Effects of Angiopoietin-2 Blockade on Tumors

Proteins in Plant Brassinosteroid Signaling

H2S to Mitigate Vascular Aging: A SIRT1 Connection

John D. Gordan, Craig B. Thompson, M. Celeste Simon Cancer Cell

Volume 10, Issue 3, Pages (September 2006)

Volume 23, Issue 6, Pages (June 2013)

All Roads Lead to the Ribosome

Co-opted integrin signaling in ErbB2-induced mammary tumor progression

Volume 25, Issue 2, Pages (January 2007)

Glycogen Synthase Kinase-3 and Cancer: Good Cop, Bad Cop?

Volume 4, Issue 4, Pages (October 2003)

Is Cyclin D1-CDK4 kinase a bona fide cancer target?

Gankyrin: An intriguing name for a novel regulator of p53 and RB

New Myc-anisms for DNA Replication and Tumorigenesis?

Volume 12, Issue 6, Pages (December 2007)

Anthony N. Imbalzano, Stephen N. Jones Cancer Cell

AMPK and p53 help cells through lean times

The Ups and Downs of Src Regulation: Tumor Suppression by Cbp

Skp2, the FoxO1 hunter Cancer Cell

Presentation transcript:

The Kinase-Independent, Second Life of CDK6 in Transcription Tobias Otto, Piotr Sicinski Cancer Cell Volume 24, Issue 2, Pages 141-143 (August 2013) DOI: 10.1016/j.ccr.2013.07.019 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 Model of the Function of CDK6 as Regulator of Cell Cycle and Angiogenesis The regulation of cell cycle and proliferation by CDK6 depends on the functionality of the p16INK4a protein. CDK6 overexpression can either cause cell cycle arrest in a cell with functional p16INK4a by activating p16INK4a transcription in a kinase-independent manner (left) or promote cell cycle progression if p16INK4a function is lost (right). In addition to regulating cell cycle, CDK6 also induces angiogenesis by activating the transcription of VEGF-A, a known angiogenic factor, in a kinase-independent manner. Cancer Cell 2013 24, 141-143DOI: (10.1016/j.ccr.2013.07.019) Copyright © 2013 Elsevier Inc. Terms and Conditions